Here are our NFL picks for Tuesday 22 September 2026. Our model likes 6 bets here. The one it likes most is Blake Corum (LA) Under 0.5 Receptions, priced at +130 when we wrote this. Here is the thinking behind each pick, in plain English.

Blake Corum (LA) Under 0.5 Receptions (+130)

Odds available at DraftKings at time of publishing

Los Angeles Rams play New York Giants in the NFL on Tuesday 22 September 2026. The bet we are looking at is Blake Corum (LA) Under 0.5 Receptions. It was priced at +130 when we wrote this, so a $10 bet returns $23 if it lands. Our model rates this one a lean pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.

Tyler Higbee (LA) Over 10.5 Receiving Yards (-120)

Odds available at FanDuel at time of publishing

Los Angeles Rams play New York Giants in the NFL on Tuesday 22 September 2026. The bet we are looking at is Tyler Higbee (LA) Over 10.5 Receiving Yards. It was priced at -120 when we wrote this, so a $10 bet returns $18.30 if it lands. Our model rates this one a lean pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.

Tutu Atwell (LA) Over 0.5 Receptions (-132)

Odds available at FanDuel at time of publishing

Los Angeles Rams play New York Giants in the NFL on Tuesday 22 September 2026. The bet we are looking at is Tutu Atwell (LA) Over 0.5 Receptions. It was priced at -132 when we wrote this, so a $10 bet returns $17.60 if it lands. Our model rates this one a strong pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.

Tyler Higbee (LA) Over 11.5 Receiving Yards (-115)

Odds available at DraftKings at time of publishing

Los Angeles Rams play New York Giants in the NFL on Tuesday 22 September 2026. The bet we are looking at is Tyler Higbee (LA) Over 11.5 Receiving Yards. It was priced at -115 when we wrote this, so a $10 bet returns $18.70 if it lands. Our model rates this one a lean pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.

Matthew Stafford (LA) Under 0.5 Interceptions Thrown (-175)

Odds available at DraftKings at time of publishing

Los Angeles Rams play New York Giants in the NFL on Tuesday 22 September 2026. The bet we are looking at is Matthew Stafford (LA) Under 0.5 Interceptions Thrown. It was priced at -175 when we wrote this, so a $10 bet returns $15.70 if it lands. Our model rates this one a strong pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.

Xavier Smith (LA) Under 16.5 Receiving Yards (-114)

Odds available at FanDuel at time of publishing

Los Angeles Rams play New York Giants in the NFL on Tuesday 22 September 2026. The bet we are looking at is Xavier Smith (LA) Under 16.5 Receiving Yards. It was priced at -114 when we wrote this, so a $10 bet returns $18.80 if it lands. Our model rates this one a lean pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.

That is the model's read on today's NFL card. Prices move, so check the price at your bookmaker before you back anything. And if a game does not feel right to you, the strongest move is to skip it -- there is another one tomorrow.

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