Here are our Serie A picks for Tuesday 15 September 2026. Our model likes 6 bets here. The one it likes most is Lecce +1.75 Goal Handicap, priced at -125 when we wrote this. Here is the thinking behind each pick, in plain English.

AC Milan vs Lecce: Lecce +1.75 Goal Handicap (-125)

Odds available at DraftKings at time of publishing

When AC Milan hosts Lecce, the narrative leans heavily in Lecce’s favor, especially with the handicap line set at 1.75. Milan's recent home form shows a shaky 2-2-1 record, averaging just 1 goal per game at home while conceding 1.6—an indication of vulnerability. Meanwhile, Lecce has turned on the style away from home with a solid 3-0-2 record in their last five games, scoring 1.4 goals on average. Their impressive xG stats suggest they’re creating chances, even if the numbers don’t fully capture their attacking potential. Historically, Milan has dominated this matchup, but current trends hint at a more competitive Lecce side. With their resilient away form and Milan’s struggles, backing Lecce at +1.75 could be a savvy play as they look to capitalize on any Milan missteps.

AC Milan vs Lecce: Lecce +2 Goal Handicap (-179)

Odds available at DraftKings at time of publishing

As AC Milan prepares to face Lecce, the stats tell a compelling story. Despite Milan's historical dominance—boasting a perfect 5-0-0 record against Lecce in their last five encounters—the current form suggests a different narrative. Milan's recent home form has been lackluster, drawing three of their last five, while averaging just one goal at home. Lecce, on the other hand, is riding a wave of confidence with a solid away record, scoring 1.4 goals on average in their travels. Their defensive resilience has been impressive too, conceding only 0.8 goals per away match. With the expectation that Lecce can keep it competitive and potentially snag at least a draw, betting on Lecce with a 2-goal handicap seems insightful. They have the momentum and are well equipped to challenge Milan, making this handicap bet a savvy play.

AC Milan vs Lecce: Lecce +1.25 Goal Handicap (+135)

Odds available at DraftKings at time of publishing

As AC Milan gears up to face Lecce, the narrative is fascinating. While Milan enjoys a historical edge with five consecutive wins against Lecce, cracks are showing in their home form, with just two wins in their last five and an average of only 1.0 goals scored at home recently. Their defense has allowed an unsettling 1.6 goals per game, raising questions about their solidity. Conversely, Lecce’s away form is more promising, boasting three wins from their last five outings. They’ve shown the ability to score, averaging 1.4 goals away while conceding only 0.8—a stark contrast to Milan's struggles. With Lecce needing to break their winless streak against Milan, the 1.25 handicap offers a sweet opportunity. This bet capitalizes on Lecce’s resilience and Milan’s recent inconsistency, making the odds of 2.35 appealing for a potentially lucrative payday.

Tottenham Hotspur vs Aston Villa: Aston Villa +0.75 Goal Handicap (-169)

Odds available at DraftKings at time of publishing

In the upcoming clash between Tottenham Hotspur and Aston Villa, the betting spotlight shines on Villa with a 0.75 handicap, and here’s why. Spurs have been struggling at home, only managing one win in their last five matches, with a disappointing average of 0.2 goals scored. Their xG stats mirror this decline, revealing a lack of creativity and finishing ability, particularly evident in their home games where they’ve averaged just 0.8 goals. On the flip side, Aston Villa has shown resilience, even if their recent away form is shaky. They’ve historically had the upper hand against Spurs, winning two of their last five encounters. With Spurs leaking goals at home and Villa finding ways to stay competitive, backing Aston Villa here feels like a calculated risk that could pay off, especially given their ability to exploit Tottenham's frailties.

New York City FC vs New York Red Bulls: Under 3.5 Total Goals (-149)

Odds available at DraftKings at time of publishing

When New York City FC hosts their city rivals, the New York Red Bulls, expect a cagey affair. Both teams have struggled to find the back of the net lately, with NYCFC averaging just one goal per game at home in their last five outings. On the flip side, the Red Bulls have been even more blunt up front, managing a paltry 0.6 goals in their last five matches overall. The underlying numbers paint a similar picture; both teams possess low expected goals (xG) averages, suggesting that scoring chances will be scarce. With NYCFC’s home defense allowing a meager 0.8 goals per match and the Red Bulls not faring any better on the road, the stage is set for a tight contest. Given the recent scoring trends and overall form, betting on under 3.5 total goals seems not just reasonable but likely.

Venezia vs Lazio: Lazio -0.25 Goal Handicap (-130)

Odds available at DraftKings at time of publishing

As Lazio heads to Venice, there's a palpable shift in momentum that favors the visitors. While Venezia has struggled at home, going winless in their last five outings, Lazio has been on a roll, winning four of their last five matches, including a commanding away performance that racked up 1.4 goals per game. Their defense has held opponents to just 0.8 goals on average, underscoring a stark contrast to Venezia, who have conceded a hefty 2.4 goals at home recently. Moreover, Lazio's recent dominance over Venezia—winning three of their last four meetings—adds another layer of confidence. With Lazio’s xG showing they create chances consistently, they’re poised to exploit Venezia’s shaky backline. This is the perfect setup for Lazio to edge past the -0.25 handicap, making this bet a strong play in what seems like a lopsided matchup.

That is the model's read on today's Serie A card. Prices move, so check the price at your bookmaker before you back anything. And if a game does not feel right to you, the strongest move is to skip it -- there is another one tomorrow.

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