Here are our Serie A picks for Wednesday 16 September 2026. Our model likes 6 bets here. The one it likes most is Lecce +2 Goal Handicap, priced at -175 when we wrote this. Here is the thinking behind each pick, in plain English.

AC Milan vs Lecce: Lecce +2 Goal Handicap (-175)

Odds available at DraftKings at time of publishing

As AC Milan prepares to host Lecce, recent form indicates a potential upset in the making. While Milan holds a historically dominant record against Lecce, their recent home performances tell a different story, with just two wins in their last five matches at San Siro. They’ve averaged only 1 goal per game while conceding 1.6, suggesting vulnerabilities in defense. On the flip side, Lecce is thriving away, boasting three wins in their last five outings, scoring an average of 1.4 goals while conceding just 0.8. Their xG stats reveal they’ve been creating more quality chances, indicating they can find the net against a faltering Milan backline. With Lecce’s recent form and Milan’s struggles, betting on Lecce with a +2 handicap could be the savvy move. They may just surprise the Rossoneri in front of their home crowd.

AC Milan vs Lecce: Lecce +1.75 Goal Handicap (-125)

Odds available at DraftKings at time of publishing

As we head into this Serie A clash, Lecce's recent form is hard to overlook. They've been solid on the road, boasting a 3-0-2 record in their last five outings, while AC Milan’s home performances have been shaky, with just two wins from their last five. The Rossoneri have struggled to convert possession into goals, averaging only 1.6 goals per game at home, and their xG figures reflect an inability to create clear-cut chances. On the flip side, Lecce has shown resilience, scoring 1.4 goals on average away, with a much better defensive record—allowing just 0.8 goals per game. Given AC Milan's dominance in past matchups, this handicap line at 1.75 presents an intriguing opportunity. Lecce's steady improvement could help them keep it close, if not snatch a result, making a bet on Lecce at +1.75 a tempting proposition.

AC Milan vs Lecce: Lecce +1.25 Goal Handicap (+135)

Odds available at DraftKings at time of publishing

As AC Milan hosts Lecce, the matchup presents an intriguing opportunity for bettors. Milan's recent form at home has been shaky, with just two wins in their last five and an average of only 1.0 goals scored in that span. Their defensive vulnerabilities have been exposed, conceding 1.6 goals on average at home. On the flip side, Lecce has found some resilience on the road, boasting a solid away record of 3-0-2 in their last five, scoring 1.4 goals per game while conceding just 0.8. Given Milan’s struggles to convert chances—averaging 4.2 shots on target and 16 shots overall at home—Lecce can capitalize on any defensive lapses. With a favorable handicap of 1.25, backing Lecce seems both smart and enticing, especially considering Milan's historical dominance may not be as reliable this time around. Expect a tight contest where Lecce could very well clinch a vital point or more.

New York City FC vs New York Red Bulls: Under 3.5 Total Goals (-145)

Odds available at DraftKings at time of publishing

In this fierce New York derby, the goals could be more elusive than usual. Both New York City FC and the Red Bulls have been struggling offensively lately, with NYCFC averaging just one goal over their last five matches and a dismal xG output. The Red Bulls have been even quieter, managing only 0.6 goals per game in their away fixtures. Historically, these teams have a tendency to engage in tightly contested battles, and their recent meetings have often seen the net remain largely untouched. With NYCFC's defensive structure tightening up and the Red Bulls unable to find their scoring touch, the likelihood of a low-scoring affair increases significantly. Given the stakes and the teams’ recent trends, betting on under 3.5 total goals feels like a prudent move.

AC Milan vs Lecce: Under 2.5 Total Goals (+126)

Odds available at FanDuel at time of publishing

When AC Milan hosts Lecce, the signs point toward a low-scoring affair. Milan's home form has been shaky, with only 1.6 goals on average in their last five matches, while they’ve conceded 1.2. Their recent history against Lecce is telling; they’ve won all five previous encounters without allowing a single goal. Lecce, on the other hand, has struggled to find the back of the net on the road, averaging just 1.4 goals but conceding 0.8. Both teams’ xG stats indicate a tendency to create fewer clear chances lately, with Milan's last five home games showing a stark lack of offensive firepower. With Lecce's inability to break the deadlock historically against the Rossoneri, betting on 'Under 2.5' total goals seems a prudent choice for this clash. The narrative speaks volumes of defensive solidity over attacking flair.

AC Milan vs Lecce: Lecce +1.5 Goal Handicap (+100)

Odds available at DraftKings at time of publishing

As AC Milan welcomes Lecce, the odds could be swaying in favor of the visitors. While Milan boasts a strong historical record against Lecce, their recent form at home tells a different story, with just two wins in their last five matches and a concerning average of 1.0 goals scored at home. Lecce, on the other hand, is riding a wave of momentum, going unbeaten in their last five outings and showing resilience in away matches, scoring an average of 1.4 goals while conceding only 0.8. The expected goals (xG) figures paint an intriguing picture too; both teams have struggled to convert chances lately, but Lecce's ability to keep things tight defensively makes them a formidable opponent. Betting on Lecce to cover a +1.5 handicap feels like a savvy play—especially with their recent unbeaten run and Milan's struggle to dominate at home.

That is the model's read on today's Serie A card. Prices move, so check the price at your bookmaker before you back anything. And if a game does not feel right to you, the strongest move is to skip it -- there is another one tomorrow.

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