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Model picks & player props
NFL
Buffalo
Thu 17 Sep 2026, 8:15 PM ET
Detroit Lions
VS
Buffalo Bills

Detroit Lions vs Buffalo Bills Prediction & Picks

Our model graded 58 markets for Detroit Lions vs Buffalo Bills and backs Under 25.5 hardest, a lean, and $100 on it returns about $222.

20
Game markets graded
38
Props graded
The model's one call for this gamethe prediction, first Free
Under 25.5 totals h1
Under 25.5 Alternate Totals H1
You bet$10 If it wins$22.20Best price+122
Our confidenceLean
Chance to win51.0%
The price says42.5%

The model graded 58 markets for Detroit Lions vs Buffalo Bills (NFL) and this is the one it backs hardest — a lean, not a lock. A $100 bet returns about $222 if it lands. This one is free — every other market and all player props are Pro. Tip-off Thu 17 Sep 2026, 8:15 PM ET at Buffalo.

This game's bets

The rest of this game's boardgraded market by market
Alternate Totals H1 Under 25.5 Lean51% chance +122
Alternate Totals H2 Members only Long-shot36% chance Members
Alternate Team Total Points Members only Long-shot36% chance Members
Alternate Team Totals H2 Members only Lean42% chance Members
Alternate Totals H1 Members only Lean43% chance Members
Alternate Totals Q1 Members only High77% chance Members
Alternate Team Totals H1 Members only Lean40% chance Members
Interceptions Thrown × 1 prop Highup to 81% Members
Receiving Yards (Alt) × 4 props Highup to 93% Members
Last Touchdown Scorer × 13 props Long-shotup to 26% Members
Receiving Yards × 3 props Highup to 71% Members
Receptions (Alt) × 3 props Highup to 91% Members
Receptions × 5 props Highup to 77% Members
Anytime TD × 6 props Long-shotup to 23% Members
High = 60%+ chance to win · Lean = 40–60% · Long-shot = under 40%
Every NFL game on today's board →

Detroit Lions and Buffalo Bills last met on Thu 17 Sep 2026: Buffalo Bills won 41-31. Their next game gets a fresh preview here the moment it is priced. Today's board: every NFL game priced right now.

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Game picks

GOOD PRICE in green
Alternate Totals H1
Under
25.5
+122
+ 19 more markets
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All 20 game markets and 38 player props for this matchup — every line, every call the model backs — plus every pick across the slate. Join 71,793+ members.

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Calibrated model vs market

Our chance vs the price, market by market
PickMarketModel lean
UnderAlternate Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals Q1The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals Q1The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H1The model likes this price 🔒 Unlock with Pro

Which price is actually worth taking?

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Injuries & who's out

Injuries & availability

Detroit Lions

  • Ennis Rakestraw Jr. CBQuestionable
  • Mekhi Wingo DTOut
  • Seth McLaughlin COut
  • Jackson Meeks WROut
  • Ahmed Hassanein DEOut
  • Bishop Fitzgerald SOut
  • Kerby Joseph SOut
  • Ben Bartch GOut
  • Devin White LBOut
  • Tom Kennedy WROut

Buffalo Bills

  • DJ Moore WRQuestionable
  • Ed Oliver DTQuestionable
Availability updated Oct 26, 1:52PM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & injury impact for this fixture

Conditions · who's out · how it moves the number
For Detroit Lions vs Buffalo Bills: Weather isn't a tracked factor for this fixture, and 12 players are listed out or questionable across both sides.
FactorThis fixture
Availability12 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

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See the weather- and injury-adjusted projected line and the model's with/without delta for this fixture. 🔒 Unlock with Pro

Player props

GOOD PRICE in green
PlayerTeamStat
Josh Allen BUF Interceptions Thrown
James Cook BUF Receiving Yards (Alt)
Ray Davis BUF Last Touchdown Scorer
Keon Coleman BUF Receiving Yards
James Cook BUF Receptions (Alt)

+ 38 player props graded for this game — the line, the call and how much to put on each, with Pro.

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Betting angles

Markets & form
MoneylineDetroit Lions to winNo line posted

Detroit Lions vs Buffalo Bills moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadDetroit Lions spreadNo line posted

Detroit Lions vs Buffalo Bills spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total PointsLions @ BillsNo line posted

Buffalo Bills vs Detroit Lions game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Detroit Lions @ Buffalo Bills — what the model found

Our model graded 58 betting markets for Detroit Lions at Buffalo Bills — 20 on the game itself and 38 on individual players. One pick is free on this page.

20
Game markets graded
38
Player bets graded

The model checked every betting market for this game and graded 58 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 57 graded calls for this game — with how much to bet on each — are for members.
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Detroit Lions vs Buffalo Bills — recent results

Buffalo Bills have won 4 of their last 5 games; Detroit Lions have won 3 of their last 5.

Buffalo Bills — last 5
ResultScoreOpponentWhere
W33–30LVAway
W37–34LARAway
L26–29NEHome
W24–16LACHome
W41–31DETHome
Detroit Lions — last 5
ResultScoreOpponentWhere
W20–17GBHome
W45–21ARIAway
L26–32CARAway
W31–24NYJHome
L31–41BUFAway

Detroit Lions vs Buffalo Bills — recent meetings

These two have met 1 time recently: Buffalo Bills won 1, Detroit Lions won 0.

DateBuffalo BillsDetroit LionsWinner
Sep 184131Buffalo Bills

Who’s out or in doubt

12 players are listed as out or in doubt for this game.

Buffalo Bills
PlayerStatus
DJ Moore WRQUESTIONABLE
Ed Oliver DTQUESTIONABLE
Detroit Lions
PlayerStatus
Ennis Rakestraw Jr. CBQUESTIONABLE
Mekhi Wingo DTOUT
Seth McLaughlin COUT
Jackson Meeks WROUT
Ahmed Hassanein DEOUT
Bishop Fitzgerald SOUT
Kerby Joseph SOUT
Ben Bartch GOUT

The full availability report — with what each missing player means for the bets — is further down this page.

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for Detroit Lions vs Buffalo Bills in the NFL. You may also see this matchup written as Lions vs Bills, or as Bills vs Lions. The most recent game between them was Thursday 17 September 2026 at Buffalo. The model has generated 20 game picks and 38 player props for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

Detroit Lions vs Buffalo Bills head-to-head record

Final scores · 4 meetings on record
Buffalo Bills 4–0 across the last 4 meetings · these games average 60.5 points (meetings on record since 2018)

Last meeting: Fri 18 Sep 2026, Detroit Lions at Buffalo Bills: the Bills won 41-31.

DateGameScoreWinner
18 Sep 2026Detroit Lions @ Buffalo Bills41–31Buffalo Bills
15 Dec 2024Buffalo Bills @ Detroit Lions42–48Buffalo Bills
24 Nov 2022Buffalo Bills @ Detroit Lions25–28Buffalo Bills
16 Dec 2018Detroit Lions @ Buffalo Bills14–13Buffalo Bills
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