Here are our Serie A picks for Sunday 6 September 2026. Our model likes 6 bets here. The one it likes most is Genoa vs Frosinone: Frosinone +1 Goal Handicap, priced at -227 when we wrote this. Here is the thinking behind each pick, in plain English.

Genoa vs Frosinone: Frosinone +1 Goal Handicap (-227)

Odds available at draftkings at time of publishing

As Genoa gears up to host Frosinone, the stats tell a compelling story. Genoa’s home form has been dismal, with five consecutive games yielding no wins and a woeful average of just 0.4 goals scored. In stark contrast, Frosinone has shown resilience away from home, racking up two wins in their last five outings, including a solid average of 1.2 goals scored. The underlying numbers also favor the visitors; while Genoa's expected goals (xG) have been nonexistent, Frosinone's attacking prowess, averaging 15 shots per game, suggests they can exploit Genoa’s shaky defense. With Frosinone having a decent record against Genoa, a bet on Frosinone to cover a -1 handicap seems not just reasonable but downright enticing. This matchup is ripe for Frosinone to take advantage of a struggling Genoa side.

Venezia vs Fiorentina: Fiorentina Draw No Bet (-125)

Odds available at draftkings at time of publishing

As Venezia prepares to host Fiorentina, recent form suggests that backing the visitors in the Draw No Bet market is a savvy move. Venezia's home record over the last five games is less than inspiring, managing just one win and a dismal average of 0.8 goals scored. Their defense has been porous, conceding an average of 2.2 goals per match. In contrast, Fiorentina, despite their own struggles, has shown a bit more resilience on the road, with a balanced approach leading to a similar scoring average. Their last five encounters with Venezia have resulted in a positive record, and a key factor here is their ability to create more opportunities, averaging 13.8 shots per game. Given these dynamics, Fiorentina's slight edge in both offensive and defensive stats makes them a compelling choice for the Draw No Bet market.

Real Madrid vs Rayo Vallecano: Under 3.5 Total Goals (+100)

Odds available at fanduel at time of publishing

As Real Madrid prepares to host Rayo Vallecano, the stage is set for a tactical battle rather than a goal-fest. The home side has been dominant, averaging 3.2 goals scored at the Bernabéu while only allowing a mere 0.8. However, recent history against Rayo suggests a more cautious affair, with their last five encounters yielding only two wins for Madrid and limited scoring opportunities. Rayo’s away form reflects struggles, managing just 1.6 goals in their last five matches and facing a Madrid defense that’s tightened up considerably. Both teams exhibit low Expected Goals metrics lately, indicating they’re not creating numerous high-quality chances. Given the context and the stakes, betting on under 3.5 total goals seems wise, as both sides might prioritize solid defensive setups over an open, high-scoring contest. Expect a tight game, perhaps ending with a scoreline that keeps the total under that threshold.

Lille vs Troyes: Under 2.5 Total Goals (+106)

Odds available at fanduel at time of publishing

As Lille prepares to host Troyes, the stage is set for what could be a tightly contested affair. Recent form suggests a low-scoring match is on the cards, with Lille averaging just 1.2 goals at home while conceding a mere 1 goal. Their attacking output has been tepid, reflected in their xG numbers, which have hovered around 0 in recent matches. Meanwhile, Troyes struggles on the road, conceding 2.4 goals per game, yet they’ve shown a similar inability to capitalize, averaging only 1 goal themselves. Both teams seem to be in a rut offensively, with Lille's last five home games producing minimal fireworks. With the stakes high and defenses likely to be on alert, expecting under 2.5 goals feels not just reasonable, but highly probable in this Ligue One matchup.

Getafe vs Celta Vigo: Over 9.5 Total Corners (+154)

Odds available at fanduel at time of publishing

As Getafe prepares to face Celta Vigo, the stage is set for a corner-heavy clash, especially with both sides struggling to find the back of the net recently. With each team averaging a mere 0.4 goals in their last five games, it’s clear they’ll be relying on set pieces to create opportunities. Getafe's home matches have seen them attempt around 8.4 shots, while they also average around 2 corners, suggesting they'll be pushing hard for chances. Celta, on the other hand, has shown a willingness to concede corners, averaging 3.2 on the road. Their recent form indicates vulnerability, making it likely that Getafe will exploit any defensive gaps. With both teams' struggles in front of goal and their tendency to generate corners, betting on over 9.5 corners seems a savvy play in what should be a tightly contested battle.

Venezia vs Fiorentina: Fiorentina -0.25 Goal Handicap (+115)

Odds available at draftkings at time of publishing

As Venezia prepares to host Fiorentina, the matchup leans heavily in favor of the visitors. Venezia's recent form at home has been dismal, managing just a solitary win in their last five matches, and averaging a paltry 0.8 goals while conceding 2.2. With an xG of zero in their last five outings, they’re struggling to create meaningful chances. Fiorentina, on the other hand, despite their own inconsistencies, have shown flashes of promise, particularly in how they pressure opponents. They’ve racked up more shots and a higher conversion rate, even if their scoring stats don’t scream confidence. With Venezia's defense wobbling, Fiorentina's ability to exploit this could make the difference. The -0.25 handicap reflects a careful balance; it’s a bet on Fiorentina to at least secure a draw, but likely victory, as they look to capitalize on Venezia's vulnerabilities.

That is the model's read on today's Serie A card. Prices move, so check the price at your bookmaker before you back anything. And if a game does not feel right to you, the strongest move is to skip it -- there is another one tomorrow.

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