Here are our Serie A picks for Thursday 3 September 2026. Our model likes 6 bets here. The one it likes most is Genoa vs Frosinone: Frosinone +0.5 Goal Handicap, priced at -105 when we wrote this. Here is the thinking behind each pick, in plain English.

Genoa vs Frosinone: Frosinone +0.5 Goal Handicap (-105)

Odds available at draftkings at time of publishing

As Genoa prepares to host Frosinone, the recent form suggests a stark imbalance that favors the visitors. Genoa has had a rough patch, managing just a single point from their last five home encounters, scoring a meager 0.6 goals per game while conceding a hefty 1.8. Their xG stats are similarly dismal, averaging zero in their last five matches, indicating a complete lack of attacking threat. Conversely, Frosinone arrives with a more robust away record, netting 1.2 goals per game and allowing just 0.4. Their recent performances reflect a growing confidence, especially against a struggling opponent. With Genoa's inability to threaten and Frosinone's uptick in form, backing Frosinone on the alternate handicap of 0.5 looks like a savvy play. Expect Frosinone to capitalize on Genoa’s vulnerabilities and secure at least a draw.

Venezia vs Fiorentina: Fiorentina Draw No Bet (-125)

Odds available at draftkings at time of publishing

As Venezia prepares to host Fiorentina, the betting landscape favors the visitors for a good reason. Fiorentina has shown a bit more resilience in recent outings, despite an overall shaky form with just one win in their last five. Their ability to create chances, averaging over 13 shots per game, speaks volumes about their attacking intent. On the flip side, Venezia's home form is worrying; they've only managed one win in their last five, averaging a meager 0.8 goals. Their defense is leaking goals too, conceding an alarming 2.2 per match over that span. The stats suggest that Fiorentina's offensive capabilities will likely exploit Venezia’s frailties. With a positive historical record against Venezia, backing Fiorentina in the Draw No Bet market seems prudent. The odds of 1.8 offer a nice balance between risk and reward, making it a compelling wager.

Genoa vs Frosinone: Frosinone +1 Goal Handicap (-227)

Odds available at draftkings at time of publishing

As Genoa prepares to host Frosinone, the trends paint a compelling picture favoring the visitors. Genoa is struggling at home, with just one win in their last five matches, averaging a mere 0.6 goals scored while conceding 1.8. Their xG of zero at home highlights a stark inability to create meaningful chances. On the flip side, Frosinone has found some rhythm on the road, netting 1.2 goals per away game recently, and demonstrating a solid average of 15 shots per match. With Frosinone also boasting a recent 2-0-3 record, their confidence is palpable. Given Genoa's defensive woes and Frosinone’s attacking prowess, betting on Frosinone to cover a one-goal handicap seems like a savvy move. The stats favor the visitors, and their upward momentum could well see them capitalize on Genoa's struggles.

Venezia vs Fiorentina: Fiorentina -0.25 Goal Handicap (+115)

Odds available at draftkings at time of publishing

Venezia has struggled mightily at home, managing just one win in their last five matches, while averaging a dismal 0.8 goals per game. Their xG figures paint an even bleaker picture, indicating a lack of offensive creativity. On the other hand, Fiorentina, despite their own recent inconsistencies, have shown resilience against Venezia in their last five meetings, boasting two wins and a draw. Their away form has also slightly improved, with a solid average of 1.6 goals conceded per match. The stats suggest Fiorentina's attack, led by a more dynamic forward line, will be key in exploiting Venezia's frailties. With Fiorentina's strength against this opponent and Venezia's inability to convert chances, backing Fiorentina at -0.25 seems a savvy move. The odds present an enticing opportunity to capitalize on a potential Fiorentina win, making this bet one to consider closely.

Real Madrid vs Rayo Vallecano: Under 3.5 Total Goals (+100)

Odds available at fanduel at time of publishing

When Real Madrid hosts Rayo Vallecano, a bet on under 3.5 total goals feels like a smart play, especially given the recent trends. Madrid has been formidable at home, boasting a perfect record in their last five matches, averaging a robust 3.2 goals while allowing a mere 0.8. However, Rayo’s attack has struggled against top-tier defenses, scoring only 1.6 goals on average in their recent outings. Moreover, the expected goals (xG) metrics reveal a similar story: Madrid's last five games have seen them dominate possession and shots, yet they’ve kept opponents to low scoring chances. Rayo Vallecano, historically, has found it tough to break through Madrid’s backline, evidenced by their meager scoring against them in recent encounters. All signs point toward a tighter affair, making under 3.5 goals a compelling option in this clash.

Real Madrid vs Rayo Vallecano: Rayo Vallecano +2.5 Goal Handicap (-135)

Odds available at draftkings at time of publishing

As Real Madrid welcomes Rayo Vallecano, the narrative suggests a surprising twist. While the Galácticos are in blistering form at home, averaging three goals while conceding just 0.8 over their last five matches, Rayo has shown resilience. Their recent away record of 2-1-2 indicates they can snag points on hostile turf, even against tougher opponents. Their last encounters with Madrid reveal a gritty pattern, with Rayo faring better than expected, boasting two draws in the last five meetings. Additionally, Real's dominance doesn't always translate to clean sheets—allowing an average of 1.8 goals in their recent games. Rayo's ability to score around 1.6 goals lately suggests they can challenge the hosts. Thus, betting on Rayo Vallecano +2.5 makes sense; they’re likely to stay competitive, and this line provides a safety net if Madrid flexes their muscles.

That is the model's read on today's Serie A card. Prices move, so check the price at your bookmaker before you back anything. And if a game does not feel right to you, the strongest move is to skip it -- there is another one tomorrow.

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