Pittsburgh Pirates vs St. Louis Cardinals Prediction and Picks, September 23, 2026

The Pittsburgh Pirates have been on a nice run, winning 6 of their last 10 games and 4 of the last 6. They also play at PNC Park, where home runs are less common, so the ball tends to stay in the yard. However, the St. Louis Cardinals have had a rough stretch, winning only 2 of their last 6 and losing 3 straight on the road. Given the Pirates' recent form and the potential for both teams to score, I like the bet for total runs to go over 8.5. With the Pirates hitting well and the Cardinals needing to bounce back, there's a good chance we see some runs. The risk here is that the combined total might not reach the mark, as our numbers suggest it could be slightly lower at about 8.3.

Pittsburgh Pirates vs St. Louis Cardinals: Pittsburgh Pirates -1.5 Spread (+190)

The Pittsburgh Pirates have been playing well lately, winning 4 of their last 6 games. They have a decent home advantage at PNC Park, where home runs are less common, making it tougher for opponents to score big. Meanwhile, the St. Louis Cardinals have struggled on the road, losing their last 3 games away from home. The Pirates have a real shot at covering the spread, but it won't be easy since our numbers suggest a very close final score. St. Louis could surprise, especially if they find their rhythm. Still, the Pirates' recent form gives them a solid chance to win by at least two runs.

That is our read — no bet on this board is a sure thing. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.