Predictions
Pittsburgh Pirates vs St. Louis Cardinals Prediction and Picks, September 23, 2026
On September 23, 2026 our model has run St. Louis Cardinals at Pittsburgh Pirates and priced every market it can. Our strongest call is Masyn Winn (STL) Under 0.5 Runs Scored (-294), which we rate HIGH confidence. We walk through all 6 bets we like in this game below. Everything below is our own number against the price the book is offering, written in plain English with how confident we are in words.
Every bet we like in this game
Konnor Griffin (PIT) Under 1.5 Hits+Runs+RBIs (+104)
Odds available at DraftKings at time of publishing
Pittsburgh Pirates play St. Louis Cardinals in the MLB. The bet we are looking at is Konnor Griffin (PIT) Under 1.5 Hits+Runs+RBIs (+104). That is a Hits+Runs+RBIs bet. It was priced at +104 when we wrote this, so a $10 bet returns $20.40 if it lands. Our model rates this one a lean pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.
Jared Jones Under 14.5 Outs Recorded (+164)
Odds available at FanDuel at time of publishing
Pittsburgh Pirates play St. Louis Cardinals in the MLB. The bet we are looking at is Jared Jones Under 14.5 Outs Recorded (+164). That is a Outs Recorded bet. It was priced at +164 when we wrote this, so a $10 bet returns $26.40 if it lands. Our model rates this one a long shot. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.
Masyn Winn (STL) Under 0.5 Runs Scored (-294)
Odds available at DraftKings at time of publishing
Pittsburgh Pirates play St. Louis Cardinals in the MLB. The bet we are looking at is Masyn Winn (STL) Under 0.5 Runs Scored (-294). That is a Runs Scored bet. It was priced at -294 when we wrote this, so a $10 bet returns $13.40 if it lands. Our model rates this one a strong pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.
Odds correct at time of publishing
Pittsburgh Pirates play St. Louis Cardinals in the MLB. The bet we are looking at is Pittsburgh Pirates vs St. Louis Cardinals: Over 7.5 Total Runs (+108). That is a alternate totals bet. It was priced at +108 when we wrote this, so a $10 bet returns $20.80 if it lands. Our model rates this one a lean pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.
Pittsburgh Pirates vs St. Louis Cardinals: Over 9 Total Runs (+191)
Odds correct at time of publishing
Pittsburgh Pirates play St. Louis Cardinals in the MLB. The bet we are looking at is Pittsburgh Pirates vs St. Louis Cardinals: Over 9 Total Runs (+191). That is a alternate totals bet. It was priced at +191 when we wrote this, so a $10 bet returns $29.10 if it lands. Our model rates this one a long shot. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.
Pittsburgh Pirates vs St. Louis Cardinals: Over 8 Total Runs (+127)
Odds correct at time of publishing
Pittsburgh Pirates play St. Louis Cardinals in the MLB. The bet we are looking at is Pittsburgh Pirates vs St. Louis Cardinals: Over 8 Total Runs (+127). That is a alternate totals bet. It was priced at +127 when we wrote this, so a $10 bet returns $22.70 if it lands. Our model rates this one a lean pick. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.
That is the whole read. Every bet above is our own number against the price on the board at the time we wrote this, and the price can move before you get on. Bet what you can afford to lose. If betting stops being fun, take a break.
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