Arizona Diamondbacks vs Chicago Cubs Prediction and Picks, August 26, 2026

The odds for the Chicago Cubs to win are offering a fair shot at nearly even money. Both the Cubs and Diamondbacks have been up and down lately, but the Cubs have consistently done well against left-handed pitchers, hitting better than the league average. They've also managed to score just over one run more than the Diamondbacks in games we've looked at. On the other hand, Arizona has struggled to keep up, often coming out behind. This matchup is close, and the Diamondbacks have shown they can hang tough, especially at home. Still, with the Cubs' strong hitting against lefties, they have a good chance to come out on top.

Arizona Diamondbacks vs Chicago Cubs: Over 8.5 Total Runs (-110)

The odds for over 8.5 total runs look promising, especially with both teams showing good hitting against left-handed pitchers. Both teams have been scoring pretty well lately, with the Cubs finishing their last games about 1.1 runs ahead on average, while the Diamondbacks have often found themselves just 1 run behind. This matchup is rated close to a coin flip, but the risk is that both teams could struggle to score early on. Overall, it feels like a good chance to see plenty of runs today!

Arizona Diamondbacks vs Chicago Cubs: Chicago Cubs -1.5 Spread (+151)

The odds are offering a nice payout for the Chicago Cubs at +151, making them an interesting pick. They have been playing well recently and have a better average against left-handed pitchers this season compared to the Diamondbacks. The Cubs have a strong hitting performance, especially against lefties, which gives them a good chance to take control in this matchup. The Diamondbacks have struggled, often falling behind in their games, which could be a big issue here. With the Cubs showing they can outscore opponents, the risk lies in how close these teams have been, as both have had their ups and downs lately. Still, Chicago seems poised to cover that spread, so it's worth considering.

That is our read — no bet on this board is a sure thing. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.