Here are our Serie A picks for Sunday 6 September 2026. Our model likes 6 bets here. The one it likes most is Genoa vs Frosinone: Frosinone +1 Goal Handicap, priced at -222 when we wrote this. Here is the thinking behind each pick, in plain English.

Genoa vs Frosinone: Frosinone +1 Goal Handicap (-222)

Odds available at draftkings at time of publishing

As we gear up for this Serie A clash, Frosinone appears poised to capitalize on Genoa's struggles. The home side has not tasted victory in their last five outings, managing a dismal average of just 0.4 goals while conceding around 2 per game. Their xG stats tell a sobering story, consistently hovering at zero, which highlights their inability to threaten opposing defenses. On the flip side, Frosinone has shown resilience, especially away from home, with a recent 1.2 goals per game average and a solid defense allowing just 0.4 goals. Their attacking prowess is amplified by a higher shot count, indicating they create opportunities effectively. Given Genoa's shaky home form and Frosinone's competitive edge, betting on Frosinone with a -1 handicap seems like a savvy move. They’re likely to take advantage of the home team’s woes and secure a much-needed victory here.

Venezia vs Fiorentina: Fiorentina Draw No Bet (-125)

Odds available at draftkings at time of publishing

As Venezia prepares to host Fiorentina, the recent form and underlying stats point decisively towards an away victory. Venezia is struggling at home, managing just one win in their last five, and their scoring average of 0.8 goals per game is alarming, especially when they’re conceding an average of 2.2. Meanwhile, Fiorentina, despite their own inconsistencies, have shown a bit more resilience away from home and managed to score 0.8 goals while limiting their opponents to 1.8 per game. Their attacking stats, with an average of 13.8 shots per match, suggest they’re creating opportunities, even if they’ve struggled to convert them recently. Given the historical context—Fiorentina has been competitive against Venezia lately—and the current trends, backing Fiorentina in the Draw No Bet market seems a wise choice. If they can capitalize on their chances, they should emerge victorious in this crucial encounter.

Valencia vs Barcelona: Valencia +2 Goal Handicap (-149)

Odds available at draftkings at time of publishing

As Valencia prepares to host Barcelona, there’s a compelling case for taking Valencia with a +2 handicap. Despite their recent struggles, Valencia has shown resilience, especially at home, where they’ve averaged 1.6 goals per match in their last five outings. Meanwhile, Barcelona, while on a solid run, has often found it difficult to shake off Valencia—over the last five encounters, they boast a mere one win against them. Valencia’s defensive solidity is evident, conceding only 1 goal per game at home, coupled with a respectable 15.6 shots on average. The xG numbers may not be flashing, but their tactical discipline offers a chance to frustrate Barcelona. Given the stakes, Valencia is likely to rise to the occasion, making a +2 handicap an enticing option for those looking to capitalize on the dynamics of this matchup.

Real Madrid vs Rayo Vallecano: Under 3.5 Total Goals (+100)

Odds available at fanduel at time of publishing

As Real Madrid prepares to host Rayo Vallecano, the stage seems set for a tactical showdown rather than a goal fest. While Madrid has been formidable at home, averaging 3.2 goals scored and just 0.8 conceded, their recent matchups against Rayo tell a different story. In their last five encounters, only two have seen more than three goals. Rayo, while competitive, has struggled to find the net, averaging just 1.6 goals in their away matches and conceding 1.8. Their attacking output has dipped, reflected in a paltry 9.6 shots per game on the road. The underlying xG numbers for both sides further support a low-scoring affair, hinting at a tight battle. With Madrid's defensive solidity at home and Rayo's recent form, betting on under 3.5 total goals appears prudent in this tense La Liga clash.

Lille vs Troyes: Under 2.5 Total Goals (+106)

Odds available at fanduel at time of publishing

As Lille prepares to host Troyes, the signs point to a low-scoring affair. Lille's recent form at home shows a tendency to grind out results, averaging just 1.2 goals scored while conceding a mere 1 across their last five. Their ability to create scoring opportunities has waned, reflected in their xG numbers that indicate a lack of real attacking threat. Troyes, too, has struggled on the road, conceding an alarming 2.4 goals per game away from home. However, their offense hasn't been much better, managing just 1 goal per game recently. With both teams leaning heavily on defensive stability and struggling to convert chances into goals, placing a bet on the 'Under 2.5' total seems prudent. Expect a battle dominated more by tactics than by scoring as both sides focus on tightening their defenses.

Getafe vs Celta Vigo: Over 9.5 Total Corners (+154)

Odds available at fanduel at time of publishing

When Getafe takes on Celta Vigo, the pitch promises to be lively, especially in corner situations. Despite their recent struggles, both teams have displayed tendencies toward creating opportunities, albeit with low goal tallies. Getafe's last five outings have averaged over eight shots per game, hinting at a proactive approach, while Celta Vigo has been equally active, generating around 5.8 shots away from home. Add to that the frequency of fouls—Getafe averaging 14.2 and Celta around 13.6—and you can expect set pieces to pile up. Both squads have also recently seen corner counts spike, making the over on 9.5 corners feel increasingly likely. With the stakes high and both teams desperate for points, expect a tactical battle that leads to plenty of corners as they push for crucial scoring chances.

That is the model's read on today's Serie A card. Prices move, so check the price at your bookmaker before you back anything. And if a game does not feel right to you, the strongest move is to skip it -- there is another one tomorrow.

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