Here are our Serie A picks for Tuesday 8 September 2026. Our model likes 6 bets here. The one it likes most is Frosinone +0 Goal Handicap, priced at +150 when we wrote this. Here is the thinking behind each pick, in plain English.

Genoa vs Frosinone: Frosinone +0 Goal Handicap (+150)

Odds available at DraftKings at time of publishing

As we look ahead to the clash between Genoa and Frosinone, it's hard to overlook the current form of both teams. Genoa is struggling, with an alarming record of five winless home games, averaging a meager 0.4 goals per match over that stretch. Their xG stats paint an even grimmer picture—essentially nonexistent, with only 1.6 shots on target per game. Meanwhile, Frosinone is riding a wave of momentum, boasting three wins in their last five matches, including solid performances away from home where they've averaged 1.2 goals per game. With their attacking prowess noticeably higher than Genoa's, Frosinone seems poised to capitalize on the hosts’ defensive vulnerabilities. Given these trends, betting on Frosinone at a handicap of 0 appears to be an astute move, as they look to extend Genoa's home woes.

Sevilla vs Valencia: Over 7.5 Total Corners (-179)

Odds available at DraftKings at time of publishing

As Sevilla prepares to host Valencia, the stage is set for an intense clash that promises plenty of action on the flanks. Both teams have shown a tendency to push forward, with Sevilla averaging a staggering 17.4 shots per game at home, while Valencia is no slouch either, racking up 14.2 shots on their travels. Given their recent form, corners are likely to pile up; Sevilla's last five home matches have seen them generate around 3.4 corners per game, and Valencia, despite their struggles, still managed to earn 1.4 away corners. With Sevilla desperately seeking to improve upon their disappointing record against Valencia—where they've failed to secure a win in five previous encounters—expect them to throw everything at their visitors. The urgency for attacking play suggests the corners will exceed the 7.5 line, making the "Over" a compelling bet in what could be a thrilling encounter.

CF Montreal vs Charlotte FC: Charlotte FC +0 Goal Handicap (+115)

Odds available at DraftKings at time of publishing

As CF Montreal faces Charlotte FC, the trends suggest a compelling case for backing Charlotte with a handicap of zero. Montreal's recent home form has been shaky, with just one win in their last five outings and a troubling average of only 1.2 goals scored while conceding 2.6. Their defense seems particularly vulnerable, reflected in their xG stats showing they haven’t created any significant chances at home. In contrast, Charlotte is riding a wave of momentum, scoring 2.2 goals per game in their last five and boasting a solid away record, including key victories over Montreal historically. With an overall upward trajectory and a potent offense, they are well-positioned to capitalize on Montreal’s struggles. Betting on Charlotte FC to at least draw here feels like a savvy move, especially considering their head-to-head advantage. They might just walk away with more than a point in this clash.

CF Montreal vs Charlotte FC: Charlotte FC Draw No Bet (+116)

Odds available at FanDuel at time of publishing

As CF Montreal prepares to face Charlotte FC, recent form leans heavily in favor of the visitors. Montreal's home struggles are evident, with just one win in their last five matches at home and an alarming average of only 1 goal scored per game. The defensive woes are equally concerning, as they’ve conceded an average of 2.6 goals in that span. Charlotte, meanwhile, is in good form away from home, winning three of their last five while averaging 1.6 goals per match. Their ability to create scoring opportunities shines through with a respectable 11.2 shots per game. With a solid head-to-head record against Montreal, including two wins in their last five encounters, backing Charlotte in the Draw No Bet market feels prudent. Given the current trends, they’re well-positioned to either win or secure a draw, making this bet an enticing option.

Real Madrid vs Rayo Vallecano: Under 4.5 Total Goals (-222)

Odds available at FanDuel at time of publishing

As Real Madrid gears up to face Rayo Vallecano, the expectation for a low-scoring affair feels well-founded. While Madrid has been electric at home, averaging 3.2 goals over their last five matches, they’ve also been remarkably stingy, allowing just 0.8 goals per game during that stretch. Rayo, on the other hand, has struggled to find the back of the net against stronger defenses, managing only 1.6 goals in their recent away outings. Madrid's defense has been airtight, highlighted by a remarkable xG against average that speaks to their ability to stifle opponents. With Rayo yet to score against them in their last five meetings, it’s plausible that this trend continues. Taking all these factors into account, betting on the 'Under 4.5' total goals seems not only prudent but likely to pay off in this tightly contested clash.

Real Madrid vs Rayo Vallecano: Rayo Vallecano +3.5 Goal Handicap (-312)

Odds available at FanDuel at time of publishing

As Real Madrid gears up to host Rayo Vallecano, the narrative suggests an intriguing twist. While Madrid boasts a formidable home record, with a staggering average of 3.2 goals scored at home in their last five matches, Rayo has shown resilience. Their recent encounters reflect a competitive spirit, with Madrid winning just two of the last five face-offs. Rayo’s form, though inconsistent, reveals a team capable of grinding out results, averaging 1.8 goals over their last five outings. The handicap of 3.5 might appear daunting, but considering Madrid’s recent slip-up against tougher rivals, Rayo could capitalize on any defensive lapses. With the home side's defensive stats indicating some vulnerabilities, this bet on Rayo Vallecano to stay within the line seems promising. Expect a spirited contest where Rayo might just surprise the odds.

That is the model's read on today's Serie A card. Prices move, so check the price at your bookmaker before you back anything. And if a game does not feel right to you, the strongest move is to skip it -- there is another one tomorrow.

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