Arizona Cardinals vs Detroit Lions Prediction & Picks, October 11, 2026

For the Arizona Cardinals to win against the Detroit Lions, they need to find a way to outscore a team that can move the ball well. While the Lions have shown they can reach the red zone nearly four times a game, the Cardinals will be playing at home, which often gives teams a boost. The Lions have allowed a lot of yards this season, especially through the air, so Arizona's chance to score could be better than expected. The Cardinals are underdogs here, but they have a real shot at pulling off an upset. The biggest risk is that the Lions have been solid on grass and can put up points. Still, with home-field advantage and the ability to expose Detroit's defensive gaps, Arizona could surprise everyone tonight.

Arizona Cardinals vs Detroit Lions: Arizona Cardinals +5.5 Point Spread (-110)

For the Arizona Cardinals to cover the spread of +5.5 against the Detroit Lions, they need to keep the game close. The Lions have struggled to stop opponents, giving up over 350 yards per game last season. That gives the Cardinals a chance to move the ball and put points on the board, especially at home where they often play better. The matchup looks tight, and our numbers show it could be almost even. With the Lions allowing a lot of yards, the Cardinals can take advantage of their defense. However, the most concrete risk is that the Lions have been strong in certain matchups, which could lead to a bigger margin of victory if they click.

Arizona Cardinals vs Detroit Lions: Under 24.5 Team Total Points (-120)

The Arizona Cardinals have a tricky matchup against the Detroit Lions, who can be tough on defense. The Lions allowed quite a few yards in 2025, giving up an average of over 350 yards a game. While they struggled against the pass, they also held up well against the run, making things harder for the Cardinals' offense. Betting on the Cardinals to score under 24.5 points looks like a smart move here. Our numbers give it a good chance of hitting, especially since the Lions have shown they can contain teams. The main risk is how closely matched these teams can be on any given day, but the Lions' solid defense gives us a reason to lean towards the under.

Arizona Cardinals vs Detroit Lions: Jameson Williams Under 51.5 Receiving Yards (-111)

The Arizona Cardinals will face off against the Detroit Lions, and this matchup could be tricky for Jameson Williams. The Lions gave up over 350 yards a game last season, which sounds bad, but they also know how to limit big plays. Williams has been averaging just over four catches per game lately, and that might not be enough to hit the higher total for receiving yards. Although the Lions have a strong offense, they also have a solid defense that can keep Williams in check. Plus, the Cardinals will be trying to focus on stopping him, which could mean fewer chances to make big plays. This makes betting on under 51.5 receiving yards for Williams a smart move, even if it doesn't guarantee a win.

Arizona Cardinals vs Detroit Lions: Jeremiyah Love Over 63.5 Rush + Rec Yards (-111)

The Arizona Cardinals take on the Detroit Lions in what should be an exciting matchup. Jeremiyah Love has been a key player for the Cardinals, and with the Lions' defense giving up over 351 yards a game last season, he has a good chance to rack up some yards. The Lions struggled to stop both the pass and the run, which makes this a great opportunity for Love to shine. While the odds are close to even, the Lions' defense could give up enough yardage to push Love over that 63.5 mark. However, the risk here is that both teams are still finding their rhythm, so it might not be a sure thing. Keep an eye on how the game unfolds!

Arizona Cardinals vs Detroit Lions: Jeremiyah Love Under 2.5 Receptions (-109)

Jeremiyah Love has been quiet lately, and the Detroit Lions' defense can be tough for new players. They've been giving up a lot of yards, but they usually hold down the number of receptions against weaker passers. The Lions allowed around 236 passing yards each game last season, which means they can pressure quarterbacks and limit their targets. Betting on under 2.5 receptions for Love feels like a smart move. Our numbers rate this pick as close to a coin flip, so it could easily go either way. The biggest risk is that Love might get some unexpected chances, especially if the game gets chaotic.

That is the whole read on this one. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.