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Model picks & player props
NFL
San Francisco
Sun 27 Sep 2026, 4:05 PM ET
Arizona Cardinals
VS
San Francisco 49ers

Arizona Cardinals vs San Francisco 49ers Prediction & Picks

Our model graded 66 markets for Arizona Cardinals vs San Francisco 49ers and backs Under 6.5 hardest, a lean, and $100 on it returns about $215.

20
Game markets graded
46
Props graded
The model's one call for this gamethe prediction, first Free
San Francisco 49ers
under 6.5 points
Under 6.5 Team Totals Q1
You bet$10 If it wins$21.50Best price+115
Our confidenceLean
Chance to win54.8%
The price says44.0%

The model graded 66 markets for Arizona Cardinals vs San Francisco 49ers (NFL) and this is the one it backs hardest — a lean, not a lock. A $100 bet returns about $215 if it lands. This one is free — every other market and all player props are Pro. Tip-off Sun 27 Sep 2026, 4:05 PM ET at San Francisco.

This game's bets

The rest of this game's boardgraded market by market
Team Totals Q1 San Francisco 49ers Under 6.5 Lean55% chance +115
Spreads Q1 Members only Lean55% chance Members
Alternate Spreads H1 Members only Lean43% chance Members
Moneyline Q1 Members only Long-shot38% chance Members
Spreads H1 Members only Lean56% chance Members
Spread Members only Lean47% chance Members
Alternate Team Total Points Members only Lean54% chance Members
Moneyline H1 Members only Long-shot34% chance Members
Team Total Members only Lean54% chance Members
Receiving Yards (Alt) × 3 props Highup to 93% Members
Receiving Yards × 3 props Highup to 72% Members
Rushing Yards × 2 props Highup to 72% Members
Passing Yards (Alt) × 1 prop Highup to 91% Members
Rushing Yards (Alt) × 2 props Highup to 85% Members
High = 60%+ chance to win · Lean = 40–60% · Long-shot = under 40%
Every NFL game on today's board →

Arizona Cardinals and San Francisco 49ers last met on Sun 27 Sep 2026: San Francisco 49ers won 36-30. Their next game gets a fresh preview here the moment it is priced. Today's board: every NFL game priced right now.

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Game picks

GOOD PRICE in green
Team Totals Q1
Under
6.5
+115
+ 19 more markets
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All 20 game markets and 46 player props for this matchup — every line, every call the model backs — plus every pick across the slate. Join 67,257+ members.

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Calibrated model vs market

Our chance vs the price, market by market
PickMarketModel lean
UnderTeam Totals Q1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsSpreads Q1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsAlternate Spreads H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsMoneyline Q1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsSpreads H1The model likes this price 🔒 Unlock with Pro
San Francisco 49ersSpreadThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
Arizona CardinalsAlternate Spreads H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsSpreads H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsAlternate Spreads H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsAlternate Spreads H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsMoneyline H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsAlternate Spreads H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
San Francisco 49ersSpreadThe model likes this price 🔒 Unlock with Pro
UnderTeam TotalThe model likes this price 🔒 Unlock with Pro
Arizona CardinalsMoneyline 3 Way H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H1The model likes this price 🔒 Unlock with Pro

Which price is actually worth taking?

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Injuries & who's out

Injuries & availability

Arizona Cardinals

  • Wydett Williams Jr. SQuestionable
  • Carson Beck QBOut
  • Starling Thomas V CBOut
  • Andrew Wingard SOut
  • Andrew Billings DTOut
  • Isaiah Adams GOut
  • Paris Johnson Jr. OTOut
  • Hunter Long TEOut

San Francisco 49ers

  • Deebo Samuel Sr. WRQuestionable
  • Kurtis Rourke QBOut
  • Marques Sigle SOut
  • James Thompson Jr. DTOut
  • Kyle Juszczyk FBOut
  • Enrique Cruz Jr. OTOut
  • Tatum Bethune LBOut
  • Nick Bosa DEOut
Availability updated Oct 12, 2:48AM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & injury impact for this fixture

Conditions · who's out · how it moves the number
For Arizona Cardinals vs San Francisco 49ers: Outdoors with 3 mph wind, 89°F — stronger wind and cold both nudge totals and the kicking game down, and 16 players are listed out or questionable across both sides.
FactorThis fixture
Roof / venueopen-air outdoor
Surfacenatural grass
Wind3 mph
Temperature89°F
Availability16 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

Pro — weather & injury-adjusted view

See the weather- and injury-adjusted projected line and the model's with/without delta for this fixture. 🔒 Unlock with Pro

Player props

GOOD PRICE in green
PlayerTeamStat
Mike Evans SF Receiving Yards (Alt)
George Kittle SF Receiving Yards
Christian McCaffrey SF Rushing Yards
Brock Purdy SF Passing Yards (Alt)
Kaelon Black SF Rushing Yards (Alt)

+ 46 player props graded for this game — the line, the call and how much to put on each, with Pro.

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Betting angles

Markets & form
MoneylineArizona Cardinals to winNo line posted

Arizona Cardinals vs San Francisco 49ers moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadSan Francisco 49ers spreadNo line posted

San Francisco 49ers vs Arizona Cardinals spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total PointsCardinals @ 49ersNo line posted

San Francisco 49ers vs Arizona Cardinals game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Arizona Cardinals @ San Francisco 49ers — what the model found

Our model graded 66 betting markets for Arizona Cardinals at San Francisco 49ers — 20 on the game itself and 46 on individual players. One pick is free on this page.

20
Game markets graded
46
Player bets graded

The model checked every betting market for this game and graded 66 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 65 graded calls for this game — with how much to bet on each — are for members.
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Arizona Cardinals vs San Francisco 49ers — recent results

San Francisco 49ers have won 5 of their last 5 games; Arizona Cardinals have won 1 of their last 5.

San Francisco 49ers — last 5
ResultScoreOpponentWhere
W32–29SEAAway
W24–14DENHome
W36–30ARIHome
W35–13MIAHome
W27–7LARAway
Arizona Cardinals — last 5
ResultScoreOpponentWhere
L21–45DETHome
L24–36NYGAway
L30–36SFAway
L7–31SEAHome
W26–14LACAway

Arizona Cardinals vs San Francisco 49ers — recent meetings

These two have met 1 time recently: San Francisco 49ers won 1, Arizona Cardinals won 0.

DateSan Francisco 49ersArizona CardinalsWinner
Sep 273630San Francisco 49ers

Who’s out or in doubt

16 players are listed as out or in doubt for this game.

San Francisco 49ers
PlayerStatus
Deebo Samuel Sr. WRQUESTIONABLE
Kurtis Rourke QBOUT
Marques Sigle SOUT
James Thompson Jr. DTOUT
Kyle Juszczyk FBOUT
Enrique Cruz Jr. OTOUT
Tatum Bethune LBOUT
Nick Bosa DEOUT
Arizona Cardinals
PlayerStatus
Wydett Williams Jr. SQUESTIONABLE
Carson Beck QBOUT
Starling Thomas V CBOUT
Andrew Wingard SOUT
Andrew Billings DTOUT
Isaiah Adams GOUT
Paris Johnson Jr. OTOUT
Hunter Long TEOUT

The full availability report — with what each missing player means for the bets — is further down this page.

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for Arizona Cardinals vs San Francisco 49ers in the NFL. You may also see this matchup written as Cardinals vs 49ers, or as 49ers vs Cardinals. The most recent game between them was Sunday 27 September 2026 at San Francisco. The model has generated 20 game picks and 46 player props for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

Arizona Cardinals vs San Francisco 49ers head-to-head record

Final scores · 23 meetings on record
Arizona Cardinals 13–10 across the last 23 meetings · these games average 47.5 points (meetings on record since 2015)

Last meeting: Sun 27 Sep 2026, Arizona Cardinals at San Francisco 49ers: the 49ers won 36-30.

DateGameScoreWinner
27 Sep 2026Arizona Cardinals @ San Francisco 49ers36–30San Francisco 49ers
16 Nov 2025San Francisco 49ers @ Arizona Cardinals22–41San Francisco 49ers
21 Sep 2025Arizona Cardinals @ San Francisco 49ers16–15San Francisco 49ers
5 Jan 2025San Francisco 49ers @ Arizona Cardinals47–24Arizona Cardinals
6 Oct 2024Arizona Cardinals @ San Francisco 49ers23–24Arizona Cardinals
17 Dec 2023San Francisco 49ers @ Arizona Cardinals29–45San Francisco 49ers
1 Oct 2023Arizona Cardinals @ San Francisco 49ers35–16San Francisco 49ers
8 Jan 2023Arizona Cardinals @ San Francisco 49ers38–13San Francisco 49ers
21 Nov 2022San Francisco 49ers @ Arizona Cardinals10–38San Francisco 49ers
7 Nov 2021Arizona Cardinals @ San Francisco 49ers17–31Arizona Cardinals

Table shows the last 10 — the record above counts all 23 meetings on file.

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