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Model picks & player props
Arizona Cardinals
VS
San Francisco 49ers

Arizona Cardinals vs San Francisco 49ers Picks & Predictions

Model updated Sep 22, 6:47AM UTC

Our model graded 20 markets for Arizona Cardinals vs San Francisco 49ers and backs Arizona Cardinals 5.5 hardest, a strong call, and $100 on it returns about $200.

NFL
San Francisco
Sun 27 Sep 2026, 8:05PM
20
Game markets graded
0
Props graded
The model's one call for this gamethe prediction, first
Arizona Cardinals 5.5 Spreads H1 +100

The model graded 20 markets for Arizona Cardinals vs San Francisco 49ers (NFL) and this is the one it backs hardest — HIGH confidence. A $100 bet returns about $200 if it lands. This one is free — every other market and all player props are Pro. Tip-off Sun 27 Sep 2026, 8:05PM at San Francisco.

Our confidenceHigh
Chance to win67.7%
The price says47.8%
Best price+100
The rest of this game's boardgraded market by market
Spreads H1 Arizona Cardinals 5.5 High68% chance +100
Moneyline 3 Way Q1 Members only Long-shot40% chance Members
Spreads H1 Members only High64% chance Members
Alternate Team Totals H1 Members only High86% chance Members
Spreads Q3 Members only High61% chance Members
Moneyline H2 Members only Long-shot39% chance Members
Alternate Team Total Points Members only High78% chance Members
Spreads H2 Members only Lean54% chance Members
High = 60%+ chance to win · Lean = 40–60% · Long-shot = under 40%
Every NFL game on today's board →
San Francisco 49ers are the model's favourite to beat Arizona Cardinals, with a 51% chance to win. Predicted score: San Francisco 49ers 26.2 – Arizona Cardinals 17.9. Kick-off Sun 27 Sep, 8:05PM at San Francisco. Best bet: Arizona Cardinals 5.5 at +100.
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Best price on this game

Odds checked in the last few minutes · 21 bookmakers compared
Winner
Cardinals4.55+354Kalshi
49ers1.27-376Kalshi
Total points
Over47.51.96-104Kalshi
Under47.52.00+100Kalshi

Arizona Cardinals vs San Francisco 49ers odds by bookmaker

21 books · best price in green
BookCardinals win49ers win49ers -8.5Over 47.5Under 47.5
Kalshi4.55+3541.27-3762.00+1001.96-1042.00+100
Bally Bet—————
BetAnySports——1.91-110——
BetMGM——1.93-108——
BetOnline——1.91-110——
betPARX—————
BetRivers—————
BetUS—————
Bovada—————
DraftKings——1.95-105——
ESPN BET——1.95-105——
Fanatics——1.95-105——
FanDuel——1.95-105——
Fliff——1.91-110——

Since the market opened: 49ers to win opened 1.22, best now 1.27; the over 47.5 opened 1.88, best now 1.96 (decimal, best book).

Every pick is logged and graded — nothing hidden after the fact. See the verified record
This gameBets like this sit in our formula’s best NFL market — 349 of 542 right (nfl alternate team total points overs)
This bet type · last timeSep 22
Over 14.5
New York Giants @ Los Angeles Rams
CASHED
STAKE $100RETURNS $132
Today’s picks post before the games start.logged in public before tip-offSee the picks page

Game picks

GOOD PRICE in green
Spreads H1
Arizona Cardinals
5.5
+100
+ 19 more markets
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All 20 game markets and 0 player props for this matchup — every line, every call the model backs — plus every pick across the slate. Join 57,699+ members.

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Calibrated model vs market

Our chance vs the price, market by market
PickMarketModel lean
Arizona CardinalsSpreads H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsMoneyline 3 Way Q1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsSpreads H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsSpreads Q3The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H1The model likes this price 🔒 Unlock with Pro
Arizona CardinalsMoneyline H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
Arizona CardinalsSpreads H2The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Totals H1The model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro
UnderAlternate Team Total PointsThe model likes this price 🔒 Unlock with Pro

Which price is actually worth taking?

Pro shows you, in plain English, how far each price is off — and how much to put on it. No maths needed on your side.

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Market intelligence for this game

Line move · best book · closing line
The market sharpened toward Arizona Cardinals on this game.

Line movement

▲ moved toward Arizona Cardinals
Exact move size 🔒 Pro

Best price right now

FanDuel
on Arizona Cardinals
Best-price gain 🔒 Pro
Derived from a multi-book scan — we publish the direction, the best-book name and our derived value only, never a raw per-book odds board.

Injuries & who's out

Injuries & availability

Arizona Cardinals

  • Max Melton CBQuestionable
  • Will Johnson CBDoubtful
  • Garrett Williams CBOut
  • Andrew Billings DTOut
  • Kitan Crawford SOut

San Francisco 49ers

  • Romello Height DEQuestionable
  • James Thompson Jr. DTDoubtful
  • Demarcus Robinson WROut
  • Mike Evans WRQuestionable
  • Brandon Aiyuk WROut
  • Jack Jones CBQuestionable
  • De'Zhaun Stribling WROut
  • Jake Tonges TEOut
Availability updated Sep 22, 12:47AM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & injury impact for this fixture

Conditions · who's out · how it moves the number
For Arizona Cardinals vs San Francisco 49ers: Outdoors with 3 mph wind, 89°F — stronger wind and cold both nudge totals and the kicking game down, and 13 players are listed out or questionable across both sides.
FactorThis fixture
Roof / venueopen-air outdoor
Surfacenatural grass
Wind3 mph
Temperature89°F
Availability13 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

Pro — weather & injury-adjusted view

See the weather- and injury-adjusted projected line and the model's with/without delta for this fixture. 🔒 Unlock with Pro

Betting angles

1 market live
MoneylineSan Francisco 49ers to winNo line posted

San Francisco 49ers vs Arizona Cardinals moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadSan Francisco 49ers spreadNo line posted

San Francisco 49ers vs Arizona Cardinals spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total PointsCardinals @ 49ersUnder 47.5 -105
60%under %

San Francisco 49ers vs Arizona Cardinals game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Arizona Cardinals @ San Francisco 49ers — what the model found

Our model graded 20 betting markets for Arizona Cardinals at San Francisco 49ers — 20 on the game itself and 0 on individual players. One pick is free on this page.

20
Game markets graded

The model checked every betting market for this game and graded 20 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 19 graded calls for this game — with how much to bet on each — are for members.
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Arizona Cardinals vs San Francisco 49ers — recent results

San Francisco 49ers have won 4 of their last 5 games; Arizona Cardinals have won 2 of their last 5.

San Francisco 49ers — last 5
ResultScoreOpponentWhere
W35–13MIAHome
W27–7LARAway
W18–12LVAway
W41–17LACAway
L13–19TENHome
Arizona Cardinals — last 5
ResultScoreOpponentWhere
L7–31SEAHome
W26–14LACAway
L38–42GBAway
L13–34DALHome
W27–14LVAway

Who’s out or in doubt

13 players are listed as out or in doubt for this game.

San Francisco 49ers
PlayerStatus
Romello Height DEQUESTIONABLE
James Thompson Jr. DTDOUBTFUL
Demarcus Robinson WROUT
Mike Evans WRQUESTIONABLE
Brandon Aiyuk WROUT
Jack Jones CBQUESTIONABLE
De'Zhaun Stribling WROUT
Jake Tonges TEOUT
Arizona Cardinals
PlayerStatus
Max Melton CBQUESTIONABLE
Will Johnson CBDOUBTFUL
Garrett Williams CBOUT
Andrew Billings DTOUT
Kitan Crawford SOUT

The full availability report — with what each missing player means for the bets — is further down this page.

Arizona Cardinals @ San Francisco 49ers — where the money went

Since betting opened on Arizona Cardinals at San Francisco 49ers, the market has moved toward Arizona Cardinals across the main game markets.

BetWhat the money did
Moneyline — Arizona Cardinals▲ Money came for this
Spread — San Francisco 49ers -9▼ Money drifted off this
Spread — Arizona Cardinals 9▲ Money came for this
Moneyline — San Francisco 49ers▼ Money drifted off this
Spread — San Francisco 49ers -9.5▼ Money drifted off this
Spread — Arizona Cardinals 9.5▲ Money came for this
Spread — San Francisco 49ers -8.5▼ Money drifted off this
Spread — Arizona Cardinals 8.5▲ Money came for this
🔒 Exact prices and how far each line moved are for members. Unlock →
Built from a multi-book scan — we publish the direction the market moved, never a raw per-book odds board.

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for Arizona Cardinals vs San Francisco 49ers in the NFL. You may also see this matchup written as Cardinals vs 49ers, or as 49ers vs Cardinals. The next scheduled game is Sunday 27 September 2026 at San Francisco. The model has generated 20 game picks for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

Head-to-head record

Final scores · 22 meetings on record
Arizona Cardinals 13–9 across the last 22 meetings · these games average 46.7 points (meetings on record since 2015)
DateGameScoreWinner
16 Nov 2025San Francisco 49ers @ Arizona Cardinals22–41San Francisco 49ers
21 Sep 2025Arizona Cardinals @ San Francisco 49ers16–15San Francisco 49ers
5 Jan 2025San Francisco 49ers @ Arizona Cardinals47–24Arizona Cardinals
6 Oct 2024Arizona Cardinals @ San Francisco 49ers23–24Arizona Cardinals
17 Dec 2023San Francisco 49ers @ Arizona Cardinals29–45San Francisco 49ers
1 Oct 2023Arizona Cardinals @ San Francisco 49ers35–16San Francisco 49ers
8 Jan 2023Arizona Cardinals @ San Francisco 49ers38–13San Francisco 49ers
21 Nov 2022San Francisco 49ers @ Arizona Cardinals10–38San Francisco 49ers
7 Nov 2021Arizona Cardinals @ San Francisco 49ers17–31Arizona Cardinals
10 Oct 2021San Francisco 49ers @ Arizona Cardinals17–10Arizona Cardinals

Table shows the last 10 — the record above counts all 22 meetings on file.

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