Los Angeles Rams vs Buffalo Bills Prediction & Picks, October 12, 2026

For this game, we need both teams to score fewer than 55 points combined. The Rams and Bills have solid defenses that can really slow down the scoring. Plus, both offenses, while talented, have shown moments where they struggle to find the end zone. The model thinks the total points will be around 51.5, which makes the under bet look good. The fact that this matchup is rated close to a coin flip means it could go either way, but with two strong defenses at play, there's a decent chance we see a lower-scoring game.

Los Angeles Rams vs Buffalo Bills: Under 28.5 Team Total Points (-111)

The Los Angeles Rams face a tough matchup against the Buffalo Bills, who have a strong defense that can really limit scoring. With both teams having solid players, it might be hard for either side to rack up a ton of points. The Rams also have some struggles on offense lately, which could keep their total points lower than expected. Taking the bet on the Rams scoring under 28.5 points seems smart here. The teams are evenly matched, but the Bills' defense has shown it can step up when needed. The biggest risk is how close the two sides are, making it tricky to predict exactly what will happen.

Los Angeles Rams vs Buffalo Bills: Kyren Williams Over 20.5 Receiving Yards (Alt) (-110)

Kyren Williams has been showing great promise lately with the ball in his hands, making him a key player for the Rams. This week, he faces the Bills, who have a solid defense but can be vulnerable against quick and shifty players like him. I think he will get enough chances to rack up over 20.5 receiving yards, especially since the Rams will likely look to utilize him in different ways. The risk here is that the game could be tightly contested, and if the Rams find themselves in a tough spot, they might not lean on their passing game as much. Still, with Kyren's current form and the opportunities he could get, I believe he has a good shot to hit that mark.

Los Angeles Rams vs Buffalo Bills: Blake Corum Over 32.5 Rushing Yards (-112)

The Los Angeles Rams are set to face the Buffalo Bills, and this could be a solid game for Blake Corum. He's been showing good form lately, and the Rams' defense has had some trouble stopping the run. With the home crowd behind them, the Rams will likely look to Corum to help move the ball and keep their offense rolling. We think Corum has a good chance to rush for over 32.5 yards. However, the Bills have a strong defense, and they could make it tough if they focus on stopping him. Still, with his recent performances, he should find some openings to break through and hit that mark.

Los Angeles Rams vs Buffalo Bills: Blake Corum Over 32.5 Rushing Yards (Alt) (-112)

The Los Angeles Rams are set to take on the Buffalo Bills, and Blake Corum has been showing some impressive skills on the ground lately. With the Rams at home, they'll be looking to capitalize on their fans' energy. Corum has a good chance to rush for over 32.5 yards, especially against a Bills defense that can sometimes struggle to stop the run. Corum's recent form suggests he could break through for more yardage than expected. However, the Bills have a strong defense, so it might not be a cakewalk for him. If the Rams can create some openings, Corum should be able to hit that mark.

That is our read — no bet on this board is a sure thing. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.