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NFL
Sun 22 Nov 2026, 8:20PM ET
Minnesota Vikings
6-2 · 3-1 awayWWWLL
VS
San Francisco 49ers
7-1 · 5-0 at homeWWWLW

Minnesota Vikings vs San Francisco 49ers prediction and odds · Sun 22 Nov

San Francisco 49ers host Minnesota Vikings on Sunday 22 November.

Sunday 22 November 2026: Minnesota Vikings at San Francisco 49ers

San Francisco 49ers host Minnesota Vikings on Sunday 22 November. The bookies' opening prices make the 49ers about a 6 in 10 chance to win. Our model's pick lands about 5 days before kickoff.
How they've been scoring this season
Minnesota VikingsSan Francisco 49ers
Won-lost6-27-1
Points scored per game18.329.4
Points allowed per game14.519.5
On the road / at home3-1 away5-0 at home
Last 5 gamesWWWLLWWWLW
Their games average 40.8 total points this season.
From the 8 Minnesota Vikings and 8 San Francisco 49ers games on our books this season.

Minnesota Vikings vs San Francisco 49ers odds

Prices for this game

Best opening price: 49ers paid $1.51, Vikings paid $2.90 (the best of 9 bookies). Prices change before kickoff.

Fair chance at the open (our read of the prices, with the bookies' cut taken out): 49ers about 6 in 10, Vikings about 4 in 10.

How much the bookies keep: about $4.82 of every $100 bet on this game.

Since betting opened: the price has barely moved.

Prices from when betting opened on Tue 10 Nov
Our pick for this game

Our model's pick lands about 5 days before kickoff. Today's NFL picks are already up: see today's NFL picks.

What matters in this game

Rest, form and schedule
  • Minnesota Vikings have lost their last 2 games.
  • On Monday 9 November, Minnesota Vikings lost 23-6 at home to Buffalo Bills. On Sunday 8 November, San Francisco 49ers beat Las Vegas Raiders 38-17 at home.
  • Home teams won just 46 of 97 NFL games in weeks 1 to 7 this season, fewer than half. See the study

From this season's final scores.

Before you bet: NFL injury report · NFL weather · NFL defense vs position

Injuries & who's out

Injuries & availability

Minnesota Vikings

  • Joshua Metellus SQuestionable
  • Blake Cashman LBOut
  • Tyrion Ingram-Dawkins DEOut
  • Jauan Jennings WROut
  • Kyler Murray QBOut
  • Jordan Addison WRQuestionable
  • T.J. Hockenson TEOut
  • Kyle Van Noy LBQuestionable
  • Demond Claiborne RBOut

San Francisco 49ers

  • Renardo Green CBQuestionable
  • Deommodore Lenoir CBQuestionable
  • Dre Greenlaw LBQuestionable
  • Mike Evans WROut
  • Trent Williams OTQuestionable
  • C.J. West DTOut
  • Upton Stout CBQuestionable
  • Gracen Halton DTOut
  • Brandon Aiyuk WROut
Availability updated Nov 14, 1:12AM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Minnesota Vikings vs San Francisco 49ers: game facts

When it starts and how they have been going

Minnesota Vikings play San Francisco 49ers on Sunday 22 November 2026. Kick-off is 8:20 PM ET. It is an NFL game.

Minnesota Vikings: last 5 results

  1. 9 Nov 2026Lostvs Buffalo Bills 6-23
  2. 1 Nov 2026Lostat Detroit Lions 15-19
  3. 25 Oct 2026Wonvs Indianapolis Colts 16-10
  4. 11 Oct 2026Wonat New Orleans Saints 23-13
  5. 4 Oct 2026Wonvs Miami Dolphins 15-10

San Francisco 49ers: last 5 results

  1. 8 Nov 2026Wonvs Las Vegas Raiders 38-17
  2. 25 Oct 2026Lostat Atlanta Falcons 20-29
  3. 19 Oct 2026Wonvs Washington Commanders 23-17
  4. 11 Oct 2026Wonat Seattle Seahawks 32-29
  5. 4 Oct 2026Wonvs Denver Broncos 24-14

Quick answers

When is Minnesota Vikings vs San Francisco 49ers? Minnesota Vikings vs San Francisco 49ers is on Sunday 22 November 2026. Kick-off is 8:20 PM ET.

How have Minnesota Vikings and San Francisco 49ers done lately? Minnesota Vikings won 3 and lost 2 of the last 5 results we hold. San Francisco 49ers won 4 and lost 1 of the last 5 results we hold.

From the final scores we hold. Newest game first.

Minnesota Vikings vs San Francisco 49ers: the season so far

From every final score this season

Minnesota Vikings are 6-2 this season and San Francisco 49ers are 7-1. San Francisco 49ers are 5-0 at home. Minnesota Vikings are 3-1 on the road. San Francisco 49ers score 29.4 points a game and let in 19.5. Minnesota Vikings score 18.3 and let in 14.5. San Francisco 49ers games have averaged 49 points in total; Minnesota Vikings games have averaged 32.8.

SeasonMinnesota VikingsSan Francisco 49ers
Won-lost6-27-1
At home3-15-0
On the road3-12-1
Points scored a game18.329.4
Points let in a game14.519.5
Points scored at home19.031.2
Points scored away17.526.3
Against winning sides2-23-0
Current runLost 2Won 1
Biggest win39-22 vs Green Bay Packers35-13 vs Miami Dolphins
Heaviest loss23-6 vs Buffalo Bills29-20 at Atlanta Falcons

Teams they have both played

  • Against Miami Dolphins: San Francisco 49ers won 35-13 at home; Minnesota Vikings won 15-10 at home.

Rest before this game

San Francisco 49ers last played on Sunday 8 November, 14 days before this game. Minnesota Vikings last played on Monday 9 November, 13 days before.

Quick answers

How are San Francisco 49ers doing this season? San Francisco 49ers are 7-1 this season: 5-0 at home and 2-1 on the road.

How many points do Minnesota Vikings score a game? Minnesota Vikings score 18.3 points a game this season and let in 14.5, across 8 games.

Wins and losses come from the final score, overtime included. “Against winning sides” counts games against teams that have won more than half their games this season.

Minnesota Vikings vs San Francisco 49ers head-to-head record

Final scores · 6 meetings on record
Even at 3–3 across the last 6 meetings · these games average 39.8 points (meetings on record since 2015)

Last meeting: Sun 15 Sep 2024, San Francisco 49ers at Minnesota Vikings: the Vikings won 23-17.

DateGameScoreWinner
15 Sep 2024San Francisco 49ers @ Minnesota Vikings23–17Minnesota Vikings
23 Oct 2023San Francisco 49ers @ Minnesota Vikings22–17Minnesota Vikings
28 Nov 2021Minnesota Vikings @ San Francisco 49ers34–26San Francisco 49ers
11 Jan 2020Minnesota Vikings @ San Francisco 49ers27–10San Francisco 49ers
9 Sep 2018San Francisco 49ers @ Minnesota Vikings24–16Minnesota Vikings
14 Sep 2015Minnesota Vikings @ San Francisco 49ers20–3San Francisco 49ers
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