Odds and preview

NFL

Sun 25 Oct 2026, 1:00PM ET

San Francisco 49ers

5-0 · 2-0 awayWWWWW

VS

Atlanta Falcons

2-3 · 0-2 at homeLLWWL

San Francisco 49ers vs Atlanta Falcons prediction and odds · Sun 25 Oct

Atlanta Falcons host San Francisco 49ers on Sunday 25 October.

Sunday 25 October 2026: San Francisco 49ers at Atlanta Falcons

Atlanta Falcons host San Francisco 49ers on Sunday 25 October. The bookies' prices make the 49ers about a 7 in 10 chance to win. Our model's pick lands about 5 days before kickoff.

How they've been scoring this season

	San Francisco 49ers	Atlanta Falcons
Won-lost	5-0	2-3
Points scored per game	30.8	23.8
Points allowed per game	18.6	24.4
On the road / at home	2-0 away	0-2 at home
Last 5 games	WWWWW	LLWWL

Their games average 48.8 total points this season.

From the 5 San Francisco 49ers and 5 Atlanta Falcons games on our books this season.

San Francisco 49ers vs Atlanta Falcons odds

Prices for this game

Best price: Falcons pay $2.88, 49ers pay $1.47 (the best of 8 bookies we checked). $100 on the 49ers returns $147.

Fair chance (our read of the prices, with the bookies' cut taken out): Falcons about 3 in 10, 49ers about 7 in 10.

How much the bookies keep: about $4.39 of every $100 bet on this game.

Since betting opened: the price has barely moved.

Our pick for this game

Our model's pick lands about 5 days before kickoff. Today's NFL picks are already up: see today's NFL picks.

Injuries & who's out

Injuries & availability

San Francisco 49ers

• Marques Sigle SDoubtful
• Kyle Juszczyk FBQuestionable
• Nick Bosa DEQuestionable
• Nick Martin LBOut
• James Thompson Jr. DTQuestionable
• Christian Kirk WROut
• Garret Wallow LBOut
• Deebo Samuel Sr. WROut

Atlanta Falcons

• Divine Deablo LBQuestionable
• C.J. Henderson CBQuestionable
• Za'Darius Smith DEQuestionable
• Yasir Abdullah LBOut

Availability updated Oct 15, 12:10AM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

San Francisco 49ers vs Atlanta Falcons head-to-head record

Final scores · 5 meetings on record

Atlanta Falcons 3–2 across the last 5 meetings · these games average 42.0 points (meetings on record since 2015)

Last meeting: Sun 19 Oct 2025, Atlanta Falcons at San Francisco 49ers: the 49ers won 20-10.

Date	Game	Score	Winner
19 Oct 2025	Atlanta Falcons @ San Francisco 49ers	20–10	San Francisco 49ers
16 Oct 2022	San Francisco 49ers @ Atlanta Falcons	28–14	Atlanta Falcons
15 Dec 2019	Atlanta Falcons @ San Francisco 49ers	22–29	Atlanta Falcons
18 Dec 2016	San Francisco 49ers @ Atlanta Falcons	41–13	Atlanta Falcons
8 Nov 2015	Atlanta Falcons @ San Francisco 49ers	17–16	San Francisco 49ers

Playing fantasy? NFL fantasy projections for this week — the same model, scored your way.

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