Detroit Tigers vs Washington Nationals Prediction and Picks, September 22, 2026

The Washington Nationals have been playing well lately, winning 6 of their last 10 games. They've also taken 4 of their last 6, which shows they are in good form heading into this matchup. The Tigers have been solid too, but the Nationals have a real shot to pull off this victory as an underdog. One thing to keep in mind is that both teams have been pretty evenly matched in their recent performances. The Tigers are at home, and home field can be an advantage, but the Nationals seem to have the momentum. With odds at +138, this bet could be worth a shot for those feeling hopeful.

Detroit Tigers vs Washington Nationals: Over 8 Total Runs (-116)

The Detroit Tigers have been on a solid run lately, winning 7 of their last 10 games. They're playing at home, which can give them a nice boost. On the other side, the Washington Nationals have also been doing well, winning 6 of their last 10. With both teams showing strong hitting recently, this game looks like it could see a lot of runs. The bet here is on the total runs going over 8. Our numbers suggest that the combined score could be around 8.6, so there's a real chance for a high-scoring game. Just keep in mind that both teams are close in form, so anything could happen.

Detroit Tigers vs Washington Nationals: Washington Nationals +1.5 Spread (-164)

The Tigers are having a good run, winning 7 of their last 10 games. However, the Nationals have also been strong lately, winning 6 of their last 10, so this matchup should be pretty close. Comerica Park can be a tricky place to play, and the Nationals seem to have what it takes to keep it competitive. Taking the Nationals with a +1.5 spread feels smart here because our numbers say they have a good chance. The biggest risk is that the Tigers have been winning more games lately, but the Nationals are not to be underestimated.

That is our read — no bet on this board is a sure thing. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.