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Model picks & player props
NFL
Philadelphia
Sun 11 Jan 2026, 4:30 PM ET
San Francisco 49ers
VS
Philadelphia Eagles

San Francisco 49ers vs Philadelphia Eagles Prediction & Picks

Our model graded 2 markets for San Francisco 49ers vs Philadelphia Eagles and backs San Francisco 49ers hardest, a lean, and $100 on it returns about $315.

2
Game markets graded
0
Props graded
The model's one call for this gamethe prediction, first Free
San Francisco 49ers
to win
San Francisco 49ers Moneyline
You bet$10 If it wins$31.50Best price+215
Our confidenceLean
Chance to win51.5%
The price says31.8%

The model graded 2 markets for San Francisco 49ers vs Philadelphia Eagles (NFL) and this is the one it backs hardest — a lean, not a lock. A $100 bet returns about $315 if it lands. This one is free — every other market and all player props are Pro. Tip-off Sun 11 Jan 2026, 4:30 PM ET at Philadelphia.

This game's bets

The rest of this game's boardgraded market by market
Moneyline San Francisco 49ers Lean51% chance +215
Spread Members only Lean53% chance Members
High = 60%+ chance to win · Lean = 40–60% · Long-shot = under 40%
Every NFL game on today's board →

San Francisco 49ers and Philadelphia Eagles last met on Sun 11 Jan 2026: San Francisco 49ers won 23-19. Their next game gets a fresh preview here the moment it is priced. Today's board: every NFL game priced right now.

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Game picks

GOOD PRICE in green
Moneyline
San Francisco 49ers
+215
+ 1 more market
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Calibrated model vs market

Our chance vs the price, market by market
PickMarketModel lean
San Francisco 49ersMoneylineThe model likes this price 🔒 Unlock with Pro
San Francisco 49ersSpreadThe model likes this price 🔒 Unlock with Pro

Which price is actually worth taking?

Pro shows you, in plain English, how far each price is off — and how much to put on it. No maths needed on your side.

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Injuries & who's out

Injuries & availability

San Francisco 49ers

  • Deebo Samuel Sr. WRQuestionable
  • Kurtis Rourke QBOut
  • Marques Sigle SOut
  • James Thompson Jr. DTOut
  • Kyle Juszczyk FBOut
  • Enrique Cruz Jr. OTOut
  • Tatum Bethune LBOut
  • Nick Bosa DEOut

Philadelphia Eagles

  • Jalyx Hunt LBQuestionable
  • Michael Carter II CBQuestionable
  • Will Shipley RBQuestionable
  • Jonathan Greenard LBOut
  • DeVonta Smith WROut
  • Drew Kendall COut
  • Marcus Epps SOut
  • Saquon Barkley RBOut
  • Hollywood Brown WROut
  • Chance Campbell LBQuestionable
Availability updated Oct 12, 3:34AM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & injury impact for this fixture

Conditions · who's out · how it moves the number
For San Francisco 49ers vs Philadelphia Eagles: Weather isn't a tracked factor for this fixture, and 18 players are listed out or questionable across both sides.
FactorThis fixture
Availability18 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

Pro — weather & injury-adjusted view

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Betting angles

Markets & form
MoneylineSan Francisco 49ers to winNo line posted

San Francisco 49ers vs Philadelphia Eagles moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadSan Francisco 49ers spreadNo line posted

San Francisco 49ers vs Philadelphia Eagles spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total Points49ers @ EaglesNo line posted

Philadelphia Eagles vs San Francisco 49ers game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

San Francisco 49ers @ Philadelphia Eagles — what the model found

Our model graded 2 betting markets for San Francisco 49ers at Philadelphia Eagles — 2 on the game itself and 0 on individual players. One pick is free on this page.

2
Game markets graded

The model checked every betting market for this game and graded 2 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 1 graded call for this game — with how much to bet on each — are for members.
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San Francisco 49ers vs Philadelphia Eagles — recent results

Philadelphia Eagles have won 2 of their last 5 games; San Francisco 49ers have won 5 of their last 5.

Philadelphia Eagles — last 5
ResultScoreOpponentWhere
L17–19JAXAway
L20–24LARHome
L7–27CHIAway
W24–20TENAway
W24–22WSHHome
San Francisco 49ers — last 5
ResultScoreOpponentWhere
W32–29SEAAway
W24–14DENHome
W36–30ARIHome
W35–13MIAHome
W27–7LARAway

San Francisco 49ers vs Philadelphia Eagles — recent meetings

These two have met 1 time recently: Philadelphia Eagles won 0, San Francisco 49ers won 1.

DatePhiladelphia EaglesSan Francisco 49ersWinner
Jan 111923San Francisco 49ers

Who’s out or in doubt

18 players are listed as out or in doubt for this game.

Philadelphia Eagles
PlayerStatus
Jalyx Hunt LBQUESTIONABLE
Michael Carter II CBQUESTIONABLE
Will Shipley RBQUESTIONABLE
Jonathan Greenard LBOUT
DeVonta Smith WROUT
Drew Kendall COUT
Marcus Epps SOUT
Saquon Barkley RBOUT
San Francisco 49ers
PlayerStatus
Deebo Samuel Sr. WRQUESTIONABLE
Kurtis Rourke QBOUT
Marques Sigle SOUT
James Thompson Jr. DTOUT
Kyle Juszczyk FBOUT
Enrique Cruz Jr. OTOUT
Tatum Bethune LBOUT
Nick Bosa DEOUT

The full availability report — with what each missing player means for the bets — is further down this page.

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for San Francisco 49ers vs Philadelphia Eagles in the NFL. You may also see this matchup written as 49ers vs Eagles, or as Eagles vs 49ers. The most recent game between them was Sunday 11 January 2026 at Philadelphia. The model has generated 2 game picks for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

San Francisco 49ers vs Philadelphia Eagles head-to-head record

Final scores · 6 meetings on record
Even at 3–3 across the last 6 meetings · these games average 42.8 points (meetings on record since 2017)

Last meeting: Sun 11 Jan 2026, San Francisco 49ers at Philadelphia Eagles: the 49ers won 23-19.

DateGameScoreWinner
11 Jan 2026San Francisco 49ers @ Philadelphia Eagles19–23San Francisco 49ers
3 Dec 2023San Francisco 49ers @ Philadelphia Eagles19–42San Francisco 49ers
29 Jan 2023San Francisco 49ers @ Philadelphia Eagles31–7Philadelphia Eagles
19 Sep 2021San Francisco 49ers @ Philadelphia Eagles11–17San Francisco 49ers
4 Oct 2020Philadelphia Eagles @ San Francisco 49ers20–25Philadelphia Eagles
29 Oct 2017San Francisco 49ers @ Philadelphia Eagles33–10Philadelphia Eagles

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