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NFL predictions for Sunday, October 25: the model backs 49ers

12 NFL games on Sunday. The model's strongest pick is 49ers to win, a HIGH-confidence call. 2 more games have a HIGH-confidence pick.

Written with our model's data and an AI writing assistant, checked against our rules. Meet our writers

Pittsburgh Steelers at New Orleans Saints

Sun Oct 25, 9:30 AM ET

The model's picks for this game are on the game page.

San Francisco 49ers at Atlanta Falcons

Sun Oct 25, 1:00 PM ET
Top pick: 49ers to win-147

HIGH — about a 6 in 10 chance by our numbers

The San Francisco 49ers are tough to beat, especially with their strong defense.

Cincinnati Bengals at Baltimore Ravens

Sun Oct 25, 1:00 PM ET
Our pick: Ravens to win+132

LEAN — about a 5 in 10 chance by our numbers

The Baltimore Ravens need to come out strong and secure a win against the Cincinnati Bengals tonight.

Tampa Bay Buccaneers at Carolina Panthers

Sun Oct 25, 1:00 PM ET
Our pick: Panthers to win-154

HIGH — about a 6 in 10 chance by our numbers

The Carolina Panthers face the Tampa Bay Buccaneers in a matchup that could be challenging for the Panthers.

New York Giants at Houston Texans

Sun Oct 25, 1:00 PM ET

The model's picks for this game are on the game page.

Indianapolis Colts at Minnesota Vikings

Sun Oct 25, 1:00 PM ET

The model's picks for this game are on the game page.

Miami Dolphins at New York Jets

Sun Oct 25, 1:00 PM ET

The model's picks for this game are on the game page.

Cleveland Browns at Tennessee Titans

Sun Oct 25, 1:00 PM ET
Cleveland Browns at Tennessee Titans · Moneyline Which side the model backs, and why · Pro

Denver Broncos at Arizona Cardinals

Sun Oct 25, 4:05 PM ET
Denver Broncos at Arizona Cardinals · Moneyline Which side the model backs, and why · Pro

Green Bay Packers at Detroit Lions

Sun Oct 25, 4:25 PM ET

The model's picks for this game are on the game page.

Los Angeles Rams at Las Vegas Raiders

Sun Oct 25, 4:25 PM ET
Los Angeles Rams at Las Vegas Raiders · Moneyline Which side the model backs, and why · Pro

Kansas City Chiefs at Seattle Seahawks

Sun Oct 25, 8:20 PM ET

The model's picks for this game are on the game page.

How we pick these games

Our model looks at each team's recent form, injuries, rest and the price on offer, and works out how likely each result is. When its number says a bet is more likely to land than the price suggests, the bet makes our list. For each game we show the one main-line bet it likes most. HIGH means it lands about 6 or more times in 10 by our numbers. LEAN means about 4 to 6 times in 10. LONG-SHOT means less than 4 in 10: a bigger payout and a smaller chance. No pick is a sure thing.

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