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Model picks & player props
San Francisco 49ers
VS
Indianapolis Colts

San Francisco 49ers vs Indianapolis Colts Picks & Predictions

Model updated Aug 31, 1:08AM UTC

We checked every price on this game against our own numbers. The green ones are the bets worth more than they should be.

NFL
Indianapolis
Tue 23 Dec 2025, 1:15AM
2
Game markets graded
0
Props graded
The model's one call for this gamethe prediction, first
Over 46.5 Total Points -105

The model graded 2 markets for San Francisco 49ers vs Indianapolis Colts (NFL) and this is the one it backs hardest — a lean, not a lock. A $100 bet returns about $195 if it lands. This one is free — every other market and all player props are Pro. Tip-off Tue 23 Dec 2025, 1:15AM at Indianapolis.

Our confidenceLean
Chance to win54.8%
The price says51.3%
Best price-105
The rest of this game's boardgraded market by market
Total Points Over 46.5 Lean55% chance -105
Total Points Lean55% chance —
High = 60%+ chance to win · Lean = 40–60% · Long-shot = under 40%
Every NFL game on today's board →
This game is done — the model’s call CASHED
Over 46.5 · $100 returned $195

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Every pick is logged and graded — nothing hidden after the fact. See the verified record

Game picks

GOOD PRICE in green
Total Points
Over
46.5
-105
+ 1 more market
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All 2 game markets and 0 player props for this matchup — every line, every call the model backs — plus every pick across the slate. Join 56,376+ members.

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Calibrated model vs market

Our chance vs the price, market by market
PickMarketModel lean
OverTotal PointsThe model likes this price 🔒 Unlock with Pro
OverTotal PointsThe model likes this price 🔒 Unlock with Pro

Which price is actually worth taking?

Pro shows you, in plain English, how far each price is off — and how much to put on it. No maths needed on your side.

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Injuries & who's out

Injuries & availability

San Francisco 49ers

  • Isaac Guerendo RBOut
  • George Kittle TEQuestionable
  • Brayden Willis TEQuestionable
  • Ephesians Prysock CBQuestionable
  • Victor Dimukeje DEOut
  • De'Zhaun Stribling WRQuestionable
  • Mike Evans WRQuestionable
  • Kurtis Rourke QBQuestionable
  • Upton Stout CBQuestionable
  • Jacob Cowing WRQuestionable
  • Romello Height DEQuestionable
  • Christian McCaffrey RBQuestionable
  • Christian Kirk WRQuestionable
  • Nick Martin LBQuestionable

Indianapolis Colts

  • Coleman Owen WRQuestionable
  • Alec Pierce WRQuestionable
  • Josh Downs WRQuestionable
  • Charvarius Ward CBQuestionable
  • Tyler Warren TEQuestionable
  • Will Mallory TEQuestionable
  • Carson Towt TEOut
  • Sean McKeon TEQuestionable
  • Cameron Mitchell CBOut
Availability updated Aug 30, 10:31PM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & injury impact for this fixture

Conditions · who's out · how it moves the number
For San Francisco 49ers vs Indianapolis Colts: Weather isn't a tracked factor for this fixture, and 23 players are listed out or questionable across both sides.
FactorThis fixture
Availability23 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

Pro — weather & injury-adjusted view

See the weather- and injury-adjusted projected line and the model's with/without delta for this fixture. 🔒 Unlock with Pro

Betting angles

Markets & form
MoneylineIndianapolis Colts to winNo line posted

Indianapolis Colts vs San Francisco 49ers moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadIndianapolis Colts spreadNo line posted

Indianapolis Colts vs San Francisco 49ers spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total Points49ers @ ColtsNo line posted

Indianapolis Colts vs San Francisco 49ers game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

San Francisco 49ers @ Indianapolis Colts — what the model found

Our model graded 2 betting markets for San Francisco 49ers at Indianapolis Colts — 2 on the game itself and 0 on individual players. One pick is free on this page.

2
Game markets graded

The model checked every betting market for this game and graded 2 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 1 graded call for this game — with how much to bet on each — are for members.
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San Francisco 49ers vs Indianapolis Colts — recent results

Indianapolis Colts have won 0 of their last 4 games; San Francisco 49ers have won 3 of their last 5.

Indianapolis Colts — last 4
ResultScoreOpponentWhere
L16–25DETHome
L6–34ATLHome
D13–13NEAway
L30–38HOUAway
San Francisco 49ers — last 5
ResultScoreOpponentWhere
W18–12LVAway
W41–17LACAway
L13–19TENHome
L6–41SEAAway
W23–19PHIAway

Who’s out or in doubt

23 players are listed as out or in doubt for this game.

Indianapolis Colts
PlayerStatus
Coleman Owen WRQUESTIONABLE
Alec Pierce WRQUESTIONABLE
Josh Downs WRQUESTIONABLE
Charvarius Ward CBQUESTIONABLE
Tyler Warren TEQUESTIONABLE
Will Mallory TEQUESTIONABLE
Carson Towt TEOUT
Sean McKeon TEQUESTIONABLE
San Francisco 49ers
PlayerStatus
Isaac Guerendo RBOUT
George Kittle TEQUESTIONABLE
Brayden Willis TEQUESTIONABLE
Ephesians Prysock CBQUESTIONABLE
Victor Dimukeje DEOUT
De'Zhaun Stribling WRQUESTIONABLE
Mike Evans WRQUESTIONABLE
Kurtis Rourke QBQUESTIONABLE

The full availability report — with what each missing player means for the bets — is further down this page.

Track record for this matchup

Logged & graded
2
Total Picks
—
Hit Rate

Hit rate is how often the pick landed — not profit; favourites can win often and still lose money.

DateMarketPickResult
23 Dec 25 Total Points Over 45.5 ✓ HIT
23 Dec 25 Total Points Over 46.5 ✓ HIT

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for San Francisco 49ers vs Indianapolis Colts in the NFL. You may also see this matchup written as 49ers vs Colts, or as Colts vs 49ers. The most recent game between them was Tuesday 23 December 2025 at Indianapolis. The model has generated 2 game picks for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

Head-to-head record

Final scores · 3 meetings on record
Indianapolis Colts 2–1 across the last 3 meetings (meetings on record since 2017)
DateGameScoreWinner
22 Dec 2025San Francisco 49ers @ Indianapolis Colts27–48San Francisco 49ers
24 Oct 2021Indianapolis Colts @ San Francisco 49ers18–30Indianapolis Colts
8 Oct 2017San Francisco 49ers @ Indianapolis Colts26–23Indianapolis Colts
Today's selected board

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