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Model picks & player props
San Francisco 49ers
VS
Indianapolis Colts

San Francisco 49ers vs Indianapolis Colts Picks & Predictions

Model updated Aug 10, 2:34PM UTC

Every play below is priced against our model. The bigger the green edge, the more the line is in your favour.

NFL
Indianapolis
Tue 23 Dec 2025, 1:15AM
4
Game markets graded
0
Props graded
Answer
The model’s one call for this game: Over 46.5 (Total Points)
The model graded 4 markets for San Francisco 49ers vs Indianapolis Colts (NFL) and this is the one it backs hardest — a lean, not a lock. A $100 bet returns about $195 if it lands. This one is free — every other market and all player props are Pro. For the numbers: model win probability 54.8%, fair odds 1.82, book price -105, model edge +3.5%. Tip-off Tue 23 Dec 2025, 1:15AM at Indianapolis.
This game is done — the model’s call CASHED
Over 46.5 · $100 returned $195

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Game picks

+EV edge in green
Total Points
Over
45.5
-115
+ 3 more markets
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Calibrated model vs market

Model prob · fair odds · edge
PickMarketModel lean
OverTotal PointsPositive-edge lean 🔒 Unlock with Pro
OverTotal PointsPositive-edge lean 🔒 Unlock with Pro

Which price is actually worth taking?

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Who's out

Injuries & availability

San Francisco 49ers

  • Christian Kirk WRQuestionable
  • Mike Evans WRQuestionable
  • De'Zhaun Stribling WRQuestionable
  • Osa Odighizuwa DTQuestionable
  • Ricky Pearsall WROut
  • Mikail Kamara DEOut
  • Kaelon Black RBQuestionable
  • Tanner McLachlan TEOut
  • Keion White DEQuestionable
  • Romello Height DEQuestionable
  • Nick Bosa DEQuestionable

Indianapolis Colts

  • Alec Pierce WROut
  • Blake Freeland OTQuestionable
  • Cameron Mitchell CBQuestionable
  • Sauce Gardner CBQuestionable
Availability updated Aug 9, 8:40PM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & availability impact for this fixture

Conditions · who's out · how it moves the number
For San Francisco 49ers vs Indianapolis Colts: Weather isn't a tracked factor for this fixture, and 15 players are listed out or questionable across both sides.
FactorThis fixture
Availability15 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

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Betting angles

Markets & form
MoneylineIndianapolis Colts to winNo line posted

Indianapolis Colts vs San Francisco 49ers moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadIndianapolis Colts spreadNo line posted

Indianapolis Colts vs San Francisco 49ers spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total Points49ers @ ColtsNo line posted

Indianapolis Colts vs San Francisco 49ers game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

San Francisco 49ers @ Indianapolis Colts — what the model found

Our model graded 4 betting markets for San Francisco 49ers at Indianapolis Colts — 4 on the game itself and 0 on individual players. One pick is free on this page.

4
Game markets graded

The model checked every betting market for this game and graded 4 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 3 graded calls for this game — with how much to bet on each — are for members.
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Who’s out or in doubt

15 players are listed as out or in doubt for this game.

Indianapolis Colts
PlayerStatus
Alec Pierce WROUT
Blake Freeland OTQUESTIONABLE
Cameron Mitchell CBQUESTIONABLE
Sauce Gardner CBQUESTIONABLE
San Francisco 49ers
PlayerStatus
Christian Kirk WRQUESTIONABLE
Mike Evans WRQUESTIONABLE
De'Zhaun Stribling WRQUESTIONABLE
Osa Odighizuwa DTQUESTIONABLE
Ricky Pearsall WROUT
Mikail Kamara DEOUT
Kaelon Black RBQUESTIONABLE
Tanner McLachlan TEOUT

The full availability report — with what each missing player means for the bets — is further down this page.

Track record for this matchup

Logged & graded
2
Total Picks
—
Hit Rate

Hit rate is how often the pick landed — not profit; favourites can win often and still lose money.

DateMarketPickResult
23 Dec 25 Total Points Over 45.5 ✓ HIT
23 Dec 25 Total Points Over 46.5 ✓ HIT

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for San Francisco 49ers vs Indianapolis Colts in the NFL. You may also see this matchup written as 49ers vs Colts, or as Colts vs 49ers. The most recent game between them was Tuesday 23 December 2025 at Indianapolis. The model has generated 4 game picks for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

Today's selected board

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