Bet Better BET BETTER PRO
Log in
Model picks & player props
San Francisco 49ers
VS
Indianapolis Colts

San Francisco 49ers vs Indianapolis Colts Picks & Predictions

Model updated Sep 20, 3:04AM UTC

Our model graded 2 markets for San Francisco 49ers vs Indianapolis Colts and backs Over 46.5 hardest, a lean, and $100 on it returns about $195.

NFL
Indianapolis
Tue 23 Dec 2025, 1:15AM
2
Game markets graded
0
Props graded
The model's one call for this gamethe prediction, first
Over 46.5 Total Points -105

The model graded 2 markets for San Francisco 49ers vs Indianapolis Colts (NFL) and this is the one it backs hardest — a lean, not a lock. A $100 bet returns about $195 if it lands. This one is free — every other market and all player props are Pro. Tip-off Tue 23 Dec 2025, 1:15AM at Indianapolis.

Our confidenceLean
Chance to win54.8%
The price says51.3%
Best price-105
The rest of this game's boardgraded market by market
Total Points Over 46.5 Lean55% chance -105
Total Points Members only Lean55% chance Members
High = 60%+ chance to win · Lean = 40–60% · Long-shot = under 40%
Every NFL game on today's board →

San Francisco 49ers and Indianapolis Colts last met on Tue 23 Dec 2025. What follows is the model's graded record from that game; a new preview appears here the moment the next one is priced. Today's board: every NFL game priced right now.

Unlock every pick for this game
This game is done — the model’s call CASHED
Over 46.5 · $100 returned $195

Get tomorrow's free pick by email

Free. One email a day, tops. Unsubscribe in one tap.

18+ only. Please gamble responsibly.

Every pick is logged and graded — nothing hidden after the fact. See the verified record
This gameBets like this sit in our formula’s best NFL market — 174 of 355 right (nfl alternate team total points overs)
This bet type · last timeSep 15
Kansas City Chiefs Over 17.5
Denver Broncos @ Kansas City Chiefs
CASHED
STAKE $100RETURNS $136
Our call on this game: — members only · unlock tonight's call2 picks on the board · logged before tip-offSee the picks

Game picks

GOOD PRICE in green
Total Points
Over
46.5
-105
+ 1 more market
Unlock with Pro
🔒
🔒

Unlock every graded pick for this game

All 2 game markets and 0 player props for this matchup — every line, every call the model backs — plus every pick across the slate. Join 57,537+ members.

Bet Better Unlock all game picks
$4.14 a day on the weekly plan ($29/wk) — less than one $50 bet · cancel anytime · full verified record at /results

Calibrated model vs market

Our chance vs the price, market by market
PickMarketModel lean
OverTotal PointsThe model likes this price 🔒 Unlock with Pro
OverTotal PointsThe model likes this price 🔒 Unlock with Pro

Which price is actually worth taking?

Pro shows you, in plain English, how far each price is off — and how much to put on it. No maths needed on your side.

Bet Better Unlock calibrated edges
Cancel anytime · full verified record at /results

Injuries & who's out

Injuries & availability

San Francisco 49ers

  • De'Zhaun Stribling WROut
  • Eddy Pineiro PKQuestionable
  • Kaelon Black RBQuestionable
  • Jake Tonges TEOut

Indianapolis Colts

  • DJ Giddens RBQuestionable
  • Ashton Dulin WROut
  • Carson Towt TEOut
  • Sean McKeon TEQuestionable
  • D.J. Montgomery WROut
Availability updated Sep 19, 9:14PM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & injury impact for this fixture

Conditions · who's out · how it moves the number
For San Francisco 49ers vs Indianapolis Colts: Weather isn't a tracked factor for this fixture, and 9 players are listed out or questionable across both sides.
FactorThis fixture
Availability9 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

Pro — weather & injury-adjusted view

See the weather- and injury-adjusted projected line and the model's with/without delta for this fixture. 🔒 Unlock with Pro

Betting angles

Markets & form
MoneylineIndianapolis Colts to winNo line posted

Indianapolis Colts vs San Francisco 49ers moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadIndianapolis Colts spreadNo line posted

Indianapolis Colts vs San Francisco 49ers spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total Points49ers @ ColtsNo line posted

Indianapolis Colts vs San Francisco 49ers game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

San Francisco 49ers @ Indianapolis Colts — what the model found

Our model graded 2 betting markets for San Francisco 49ers at Indianapolis Colts — 2 on the game itself and 0 on individual players. One pick is free on this page.

2
Game markets graded

The model checked every betting market for this game and graded 2 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 1 graded call for this game — with how much to bet on each — are for members.
Unlock every pick
$4.14 a day on the weekly plan ($29/wk) — less than one $50 bet · cancel anytime

San Francisco 49ers vs Indianapolis Colts — recent results

Indianapolis Colts have won 0 of their last 5 games; San Francisco 49ers have won 3 of their last 5.

Indianapolis Colts — last 5
ResultScoreOpponentWhere
L23–41BALHome
L16–25DETHome
L6–34ATLHome
D13–13NEAway
L30–38HOUAway
San Francisco 49ers — last 5
ResultScoreOpponentWhere
W27–7LARAway
W18–12LVAway
W41–17LACAway
L13–19TENHome
L6–41SEAAway

Who’s out or in doubt

9 players are listed as out or in doubt for this game.

Indianapolis Colts
PlayerStatus
DJ Giddens RBQUESTIONABLE
Ashton Dulin WROUT
Carson Towt TEOUT
Sean McKeon TEQUESTIONABLE
D.J. Montgomery WROUT
San Francisco 49ers
PlayerStatus
De'Zhaun Stribling WROUT
Eddy Pineiro PKQUESTIONABLE
Kaelon Black RBQUESTIONABLE
Jake Tonges TEOUT

The full availability report — with what each missing player means for the bets — is further down this page.

Track record for this matchup

Logged & graded
2
Total Picks
—
Hit Rate

Hit rate is how often the pick landed — not profit; favourites can win often and still lose money.

DateMarketPickResult
23 Dec 25 Total Points Over 46.5 ✓ HIT
23 Dec 25 Total Points Over 45.5 ✓ HIT

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for San Francisco 49ers vs Indianapolis Colts in the NFL. You may also see this matchup written as 49ers vs Colts, or as Colts vs 49ers. The most recent game between them was Tuesday 23 December 2025 at Indianapolis. The model has generated 2 game picks for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

Head-to-head record

Final scores · 3 meetings on record
Indianapolis Colts 2–1 across the last 3 meetings (meetings on record since 2017)
DateGameScoreWinner
22 Dec 2025San Francisco 49ers @ Indianapolis Colts27–48San Francisco 49ers
24 Oct 2021Indianapolis Colts @ San Francisco 49ers18–30Indianapolis Colts
8 Oct 2017San Francisco 49ers @ Indianapolis Colts26–23Indianapolis Colts

Playing fantasy? NFL fantasy projections for this week — the same model, scored your way.

Today's selected board

See the plays that cleared the model's filter today

See today's picks

Get tomorrow's free pick by email

Free. One email a day, tops. Unsubscribe in one tap.

18+ only. Please gamble responsibly.

Bet Better is not a bookmaker and does not accept wagers. Information is for educational purposes only. Gamble responsibly — only bet what you can afford to lose. 18+. National Gambling Helpline 1800 858 858. If betting stops being fun, take a break — see our responsible gambling resources.

Get tomorrow's free pick by email

Free. One email a day, tops. Unsubscribe in one tap.

18+ only. Please gamble responsibly.