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Model picks & player props
NFL
Indianapolis
Mon 22 Dec 2025, 8:15 PM ET
San Francisco 49ers
VS
Indianapolis Colts

San Francisco 49ers vs Indianapolis Colts Prediction & Picks

Our model graded 2 markets for San Francisco 49ers vs Indianapolis Colts and backs Over 46.5 hardest, a lean, and $100 on it returns about $195.

2
Game markets graded
0
Props graded
The model's one call for this gamethe prediction, first Free
Over 46.5 total points
Over 46.5 Total Points
You bet$10 If it wins$19.52Best price-105
Our confidenceLean
Chance to win54.8%
The price says51.3%

The model graded 2 markets for San Francisco 49ers vs Indianapolis Colts (NFL) and this is the one it backs hardest — a lean, not a lock. A $100 bet returns about $195 if it lands. This one is free — every other market and all player props are Pro. Tip-off Mon 22 Dec 2025, 8:15 PM ET at Indianapolis.

This game's bets

The rest of this game's boardgraded market by market
Total Points Over 46.5 Lean55% chance -105
Total Points Members only Lean55% chance Members
High = 60%+ chance to win · Lean = 40–60% · Long-shot = under 40%
Every NFL game on today's board →

San Francisco 49ers and Indianapolis Colts last met on Mon 22 Dec 2025. Their next game gets a fresh preview here the moment it is priced. Today's board: every NFL game priced right now.

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Game picks

GOOD PRICE in green
Total Points
Over
46.5
-105
+ 1 more market
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Calibrated model vs market

Our chance vs the price, market by market
PickMarketModel lean
OverTotal PointsThe model likes this price 🔒 Unlock with Pro
OverTotal PointsThe model likes this price 🔒 Unlock with Pro

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Injuries & who's out

Injuries & availability

San Francisco 49ers

  • James Thompson Jr. DTOut
  • Upton Stout CBQuestionable
  • Nick Bosa DEOut
  • Marques Sigle SOut
  • Kyle Juszczyk FBOut
  • Christian Kirk WROut

Indianapolis Colts

  • Arden Key DEOut
  • Darius Slayton WROut
  • Jaylon Carlies LBOut
  • Charvarius Ward CBQuestionable
  • Will Mallory TEOut
  • Ashton Dulin WROut
  • Keenan Allen WRQuestionable
Availability updated Oct 10, 5:51PM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & injury impact for this fixture

Conditions · who's out · how it moves the number
For San Francisco 49ers vs Indianapolis Colts: Weather isn't a tracked factor for this fixture, and 13 players are listed out or questionable across both sides.
FactorThis fixture
Availability13 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

Pro — weather & injury-adjusted view

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Betting angles

Markets & form
MoneylineIndianapolis Colts to winNo line posted

Indianapolis Colts vs San Francisco 49ers moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadIndianapolis Colts spreadNo line posted

Indianapolis Colts vs San Francisco 49ers spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total Points49ers @ ColtsNo line posted

Indianapolis Colts vs San Francisco 49ers game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

San Francisco 49ers @ Indianapolis Colts — what the model found

Our model graded 2 betting markets for San Francisco 49ers at Indianapolis Colts — 2 on the game itself and 0 on individual players. One pick is free on this page.

2
Game markets graded

The model checked every betting market for this game and graded 2 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 1 graded call for this game — with how much to bet on each — are for members.
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San Francisco 49ers vs Indianapolis Colts — recent results

Indianapolis Colts have won 2 of their last 5 games; San Francisco 49ers have won 5 of their last 5.

Indianapolis Colts — last 5
ResultScoreOpponentWhere
W30–13WSHAway
W19–17HOUHome
L30–33KCAway
L23–41BALHome
L16–25DETHome
San Francisco 49ers — last 5
ResultScoreOpponentWhere
W24–14DENHome
W36–30ARIHome
W35–13MIAHome
W27–7LARAway
W18–12LVAway

Who’s out or in doubt

13 players are listed as out or in doubt for this game.

Indianapolis Colts
PlayerStatus
Arden Key DEOUT
Darius Slayton WROUT
Jaylon Carlies LBOUT
Charvarius Ward CBQUESTIONABLE
Will Mallory TEOUT
Ashton Dulin WROUT
Keenan Allen WRQUESTIONABLE
San Francisco 49ers
PlayerStatus
James Thompson Jr. DTOUT
Upton Stout CBQUESTIONABLE
Nick Bosa DEOUT
Marques Sigle SOUT
Kyle Juszczyk FBOUT
Christian Kirk WROUT

The full availability report — with what each missing player means for the bets — is further down this page.

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for San Francisco 49ers vs Indianapolis Colts in the NFL. You may also see this matchup written as 49ers vs Colts, or as Colts vs 49ers. The most recent game between them was Monday 22 December 2025 at Indianapolis. The model has generated 2 game picks for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

San Francisco 49ers vs Indianapolis Colts head-to-head record

Final scores · 3 meetings on record
Indianapolis Colts 2–1 across the last 3 meetings (meetings on record since 2017)

Last meeting: Mon 22 Dec 2025, San Francisco 49ers at Indianapolis Colts: the 49ers won 48-27.

DateGameScoreWinner
22 Dec 2025San Francisco 49ers @ Indianapolis Colts27–48San Francisco 49ers
24 Oct 2021Indianapolis Colts @ San Francisco 49ers18–30Indianapolis Colts
8 Oct 2017San Francisco 49ers @ Indianapolis Colts26–23Indianapolis Colts

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