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MLB predictions for Tuesday, September 22: Over 6.5 runs in Cleveland Guardians at Boston Red Sox

14 MLB games on Tuesday. The model's strongest pick is Over 6.5 runs, a HIGH-confidence call. 1 more game has a HIGH-confidence pick.

By Samantha Chen · Published Sep 21, 12:00 AM ET · Updated Sep 22, 10:53 PM ET

Written with our model's data and an AI writing assistant, checked against our rules. Meet our writers

These were our picks for Tuesday, September 22. See today's MLB predictions

Toronto Blue Jays at Baltimore Orioles

Tue Sep 22, 6:35 PM ET
Our pick: Over 7.5 runs+104

LEAN — about a 5 in 10 chance by our numbers

Full Toronto Blue Jays at Baltimore Orioles preview →

Washington Nationals at Detroit Tigers

Tue Sep 22, 6:40 PM ET
Our pick: Over 8 runs-115

LEAN — about a 4 in 10 chance by our numbers

Both the Detroit Tigers and Washington Nationals have shown some good hitting lately, winning most of their recent games.

Full Washington Nationals at Detroit Tigers preview →

Milwaukee Brewers at Philadelphia Phillies

Tue Sep 22, 6:40 PM ET
Milwaukee Brewers at Philadelphia Phillies · Total Runs Which side the model backs, and why · Pro
Full Milwaukee Brewers at Philadelphia Phillies preview →

St. Louis Cardinals at Pittsburgh Pirates

Tue Sep 22, 6:40 PM ET
St. Louis Cardinals at Pittsburgh Pirates · Spread Which side the model backs, and why · Pro
Full St. Louis Cardinals at Pittsburgh Pirates preview →

Cleveland Guardians at Boston Red Sox

Tue Sep 22, 6:45 PM ET
Top pick: Over 6.5 runs+104

HIGH — about a 6 in 10 chance by our numbers

Full Cleveland Guardians at Boston Red Sox preview →

Tampa Bay Rays at New York Yankees

Tue Sep 22, 7:05 PM ET
Tampa Bay Rays at New York Yankees · Total Runs Which side the model backs, and why · Pro
Full Tampa Bay Rays at New York Yankees preview →

Cincinnati Reds at Atlanta Braves

Tue Sep 22, 7:15 PM ET
Cincinnati Reds at Atlanta Braves · Total Runs Which side the model backs, and why · Pro
Full Cincinnati Reds at Atlanta Braves preview →

Miami Marlins at Chicago Cubs

Tue Sep 22, 7:40 PM ET
Miami Marlins at Chicago Cubs · Total Runs Which side the model backs, and why · Pro
Full Miami Marlins at Chicago Cubs preview →

Chicago White Sox at Kansas City Royals

Tue Sep 22, 7:40 PM ET
Chicago White Sox at Kansas City Royals · Total Runs Which side the model backs, and why · Pro
Full Chicago White Sox at Kansas City Royals preview →

New York Mets at Texas Rangers

Tue Sep 22, 8:05 PM ET
New York Mets at Texas Rangers · Total Runs Which side the model backs, and why · Pro
Full New York Mets at Texas Rangers preview →

Arizona Diamondbacks at Colorado Rockies

Tue Sep 22, 8:40 PM ET
Arizona Diamondbacks at Colorado Rockies · Spread Which side the model backs, and why · Pro
Full Arizona Diamondbacks at Colorado Rockies preview →

Houston Astros at Seattle Mariners

Tue Sep 22, 9:40 PM ET
Houston Astros at Seattle Mariners · Total Runs Which side the model backs, and why · Pro
Full Houston Astros at Seattle Mariners preview →

Minnesota Twins at San Francisco Giants

Tue Sep 22, 9:45 PM ET
Minnesota Twins at San Francisco Giants · Total Runs Which side the model backs, and why · Pro
Full Minnesota Twins at San Francisco Giants preview →

San Diego Padres at Los Angeles Dodgers

Tue Sep 22, 10:10 PM ET
San Diego Padres at Los Angeles Dodgers · Total Runs Which side the model backs, and why · Pro
Full San Diego Padres at Los Angeles Dodgers preview →
How we pick these games

Our model looks at each team's recent form, injuries, rest and the price on offer, and works out how likely each result is. When its number says a bet is more likely to land than the price suggests, the bet makes our list. For each game we show the one main-line bet it likes most. HIGH means it lands about 6 or more times in 10 by our numbers. LEAN means about 4 to 6 times in 10. LONG-SHOT means less than 4 in 10: a bigger payout and a smaller chance. No pick is a sure thing.

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