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NCAAF
Sat 21 Nov 2026, 3:30PM ET
Pittsburgh Panthers
6-4 · 1-2 awayLLLWL
VS
Louisville Cardinals
6-3 · 4-1 at homeLWWWW

Pittsburgh Panthers vs Louisville Cardinals prediction and odds · Sat 21 Nov

Louisville Cardinals host Pittsburgh Panthers on Saturday 21 November.

Saturday 21 November 2026: Pittsburgh Panthers at Louisville Cardinals

Louisville Cardinals host Pittsburgh Panthers on Saturday 21 November. The bookies' prices make Louisville Cardinals about an 8 in 10 chance to win. Our model's pick lands about 4 days before kickoff.
How they've been scoring this season
Pittsburgh PanthersLouisville Cardinals
Won-lost6-46-3
Points scored per game29.740.8
Points allowed per game19.425.9
On the road / at home1-2 away4-1 at home
Last 5 gamesLLLWLLWWWW
Their games average 57.9 total points this season.
From the 10 Pittsburgh Panthers and 9 Louisville Cardinals games on our books this season.

Pittsburgh Panthers vs Louisville Cardinals odds

Prices for this game

Best price: Louisville Cardinals pay $1.19, Pittsburgh Panthers pay $4.90 (the best of 6 bookies we checked). $100 on Louisville Cardinals returns $119.

Fair chance (our read of the prices, with the bookies' cut taken out): Louisville Cardinals about 8 in 10, Pittsburgh Panthers about 2 in 10.

How much the bookies keep: about $4.84 of every $100 bet on this game.

Since betting opened: the price has barely moved.

Our pick for this game

Our model's pick lands about 4 days before kickoff. Today's NCAAF picks are already up: see today's NCAAF picks.

What matters in this game

Rest, form and schedule
  • Louisville Cardinals won 4 straight games up to Saturday 7 November.
  • On Friday 13 November, Pittsburgh Panthers lost 16-10 at home to Florida State Seminoles. On Saturday 7 November, Louisville Cardinals beat Georgia Tech Yellow Jackets 44-17 on the road.
  • In their 5 games up to Friday 13 November, Pittsburgh Panthers scored 21.0 points a game, down from 29.7 across the season.
  • Home teams won 224 of the 363 college football games in our 2026 study, about 6 in 10. See the study

From this season's final scores.

Pittsburgh Panthers vs Louisville Cardinals: game facts

When it starts and how they have been going

Pittsburgh Panthers play Louisville Cardinals on Saturday 21 November 2026. Kick-off is 3:30 PM ET. It is a college football game.

Pittsburgh Panthers: last 5 results

  1. 13 Nov 2026Lostvs Florida State Seminoles 10-16
  2. 31 Oct 2026Wonvs Georgia Tech Yellow Jackets 34-11
  3. 24 Oct 2026Lostat Miami Hurricanes 23-52
  4. 17 Oct 2026Lostat Boston College Eagles 21-27
  5. 10 Oct 2026Lostvs North Carolina Tar Heels 17-21

Louisville Cardinals: last 5 results

  1. 7 Nov 2026Wonat Georgia Tech Yellow Jackets 44-17
  2. 31 Oct 2026Wonvs Stanford Cardinal 52-24
  3. 17 Oct 2026Wonat Syracuse Orange 34-26
  4. 9 Oct 2026Wonvs Florida State Seminoles 44-20
  5. 3 Oct 2026Lostat NC State Wolfpack 28-31

Quick answers

When is Pittsburgh Panthers vs Louisville Cardinals? Pittsburgh Panthers vs Louisville Cardinals is on Saturday 21 November 2026. Kick-off is 3:30 PM ET.

How have Pittsburgh Panthers and Louisville Cardinals done lately? Pittsburgh Panthers won 1 and lost 4 of the last 5 results we hold. Louisville Cardinals won 4 and lost 1 of the last 5 results we hold.

From the final scores we hold. Newest game first.

Pittsburgh Panthers vs Louisville Cardinals: the season so far

From every final score this season

Pittsburgh Panthers are 6-4 this season and Louisville Cardinals are 6-3. Louisville Cardinals are 4-1 at home. Pittsburgh Panthers are 1-2 on the road. Louisville Cardinals score 41 points a game and let in 25.9. Pittsburgh Panthers score 29.7 and let in 19.4. Louisville Cardinals games have averaged 67 points in total; Pittsburgh Panthers games have averaged 49. Louisville Cardinals have won their last 4.

SeasonPittsburgh PanthersLouisville Cardinals
Won-lost6-46-3
At home5-24-1
On the road1-22-2
Points scored a game29.741
Points let in a game19.425.9
Points scored at home31.145
Points scored away26.336.0
Against winning sides2-21-2
Current runLost 1Won 4
Biggest win59-0 vs Bucknell Bison59-13 vs Villanova Wildcats
Heaviest loss52-23 at Miami Hurricanes31-28 at NC State Wolfpack

Teams they have both played

  • Against Georgia Tech Yellow Jackets: Louisville Cardinals won 44-17 on the road; Pittsburgh Panthers won 34-11 at home.
  • Against Syracuse Orange: Louisville Cardinals won 34-26 on the road; Pittsburgh Panthers won 27-13 at home.
  • Against Florida State Seminoles: Louisville Cardinals won 44-20 at home; Pittsburgh Panthers lost 10-16 at home.

Rest before this game

Louisville Cardinals last played on Saturday 7 November, 14 days before this game. Pittsburgh Panthers last played on Friday 13 November, 8 days before. Louisville Cardinals get the longer rest.

Quick answers

How are Louisville Cardinals doing this season? Louisville Cardinals are 6-3 this season: 4-1 at home and 2-2 on the road.

How many points do Pittsburgh Panthers score a game? Pittsburgh Panthers score 29.7 points a game this season and let in 19.4, across 10 games.

Wins and losses come from the final score, overtime included. “Against winning sides” counts games against teams that have won more than half their games this season.

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