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MLB predictions for Friday, September 25: Over 6.5 runs in Chicago Cubs at Boston Red Sox

14 MLB games on Friday. The model's strongest pick is Over 6.5 runs, a HIGH-confidence call.

By Samantha Chen · Published Sep 24, 12:00 AM ET · Updated Sep 25, 11:31 PM ET

Written with our model's data and an AI writing assistant, checked against our rules. Meet our writers

These were our picks for Friday, September 25. See today's MLB predictions

Baltimore Orioles at New York Yankees

Fri Sep 25, 4:10 PM ET
Our pick: Yankees to win-106

LEAN — about a 5 in 10 chance by our numbers

Full Baltimore Orioles at New York Yankees preview →

Chicago Cubs at Boston Red Sox

Fri Sep 25, 5:35 PM ET
Top pick: Over 6.5 runs-120

HIGH — about a 6 in 10 chance by our numbers

The Boston Red Sox have been finding their rhythm lately, winning 5 of their last 10 games and 3 of their last 6.

Full Chicago Cubs at Boston Red Sox preview →

Pittsburgh Pirates at Detroit Tigers

Fri Sep 25, 6:40 PM ET
Our pick: Over 8.5 runs+109

LONG-SHOT — about a 3 in 10 chance by our numbers

The Detroit Tigers and Pittsburgh Pirates both have some struggles lately, but the Tigers can hit well at home.

Full Pittsburgh Pirates at Detroit Tigers preview →

Tampa Bay Rays at Philadelphia Phillies

Fri Sep 25, 6:40 PM ET
Tampa Bay Rays at Philadelphia Phillies · Total Runs Which side the model backs, and why · Pro
Full Tampa Bay Rays at Philadelphia Phillies preview →

New York Mets at Washington Nationals

Fri Sep 25, 6:45 PM ET
New York Mets at Washington Nationals · Total Runs Which side the model backs, and why · Pro
Full New York Mets at Washington Nationals preview →

Cincinnati Reds at Toronto Blue Jays

Fri Sep 25, 7:07 PM ET
Cincinnati Reds at Toronto Blue Jays · Total Runs Which side the model backs, and why · Pro
Full Cincinnati Reds at Toronto Blue Jays preview →

Atlanta Braves at Miami Marlins

Fri Sep 25, 7:10 PM ET
Atlanta Braves at Miami Marlins · Spread Which side the model backs, and why · Pro
Full Atlanta Braves at Miami Marlins preview →

Colorado Rockies at Chicago White Sox

Fri Sep 25, 7:40 PM ET
Colorado Rockies at Chicago White Sox · Spread Which side the model backs, and why · Pro
Full Colorado Rockies at Chicago White Sox preview →

Cleveland Guardians at Kansas City Royals

Fri Sep 25, 7:40 PM ET
Cleveland Guardians at Kansas City Royals · Total Runs Which side the model backs, and why · Pro
Full Cleveland Guardians at Kansas City Royals preview →

St. Louis Cardinals at Milwaukee Brewers

Fri Sep 25, 7:40 PM ET
St. Louis Cardinals at Milwaukee Brewers · Total Runs Which side the model backs, and why · Pro
Full St. Louis Cardinals at Milwaukee Brewers preview →

Texas Rangers at Minnesota Twins

Fri Sep 25, 8:11 PM ET
Texas Rangers at Minnesota Twins · Total Runs Which side the model backs, and why · Pro
Full Texas Rangers at Minnesota Twins preview →

Arizona Diamondbacks at San Diego Padres

Fri Sep 25, 9:40 PM ET
Arizona Diamondbacks at San Diego Padres · Total Runs Which side the model backs, and why · Pro
Full Arizona Diamondbacks at San Diego Padres preview →

Los Angeles Angels at Seattle Mariners

Fri Sep 25, 10:10 PM ET
Los Angeles Angels at Seattle Mariners · Total Runs Which side the model backs, and why · Pro
Full Los Angeles Angels at Seattle Mariners preview →

Los Angeles Dodgers at San Francisco Giants

Fri Sep 25, 10:15 PM ET
Los Angeles Dodgers at San Francisco Giants · Total Runs Which side the model backs, and why · Pro
Full Los Angeles Dodgers at San Francisco Giants preview →
How we pick these games

Our model looks at each team's recent form, injuries, rest and the price on offer, and works out how likely each result is. When its number says a bet is more likely to land than the price suggests, the bet makes our list. For each game we show the one main-line bet it likes most. HIGH means it lands about 6 or more times in 10 by our numbers. LEAN means about 4 to 6 times in 10. LONG-SHOT means less than 4 in 10: a bigger payout and a smaller chance. No pick is a sure thing.

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