Arizona Cardinals vs Denver Broncos Prediction & Picks, October 25, 2026

The Arizona Cardinals have been showing some solid play lately, putting together a few good performances. They've got the home advantage, which often helps teams play better. With the Broncos coming in, this matchup feels pretty balanced, but the Cardinals seem to have a good shot at winning. While the Broncos have a strong defense, the Cardinals' offense can surprise them. The biggest concern is how close these teams are in skill. Still, taking the Cardinals to win at these odds feels smart, especially since they're underdogs with a real chance to pull off the upset.

Arizona Cardinals vs Denver Broncos: Bo Nix Under 10.5 Rushing Yards (-110)

For the Cardinals and Broncos game, we're looking at Bo Nix and betting on him to rush for under 10.5 yards. This looks like a smart play because Nix has struggled to find running room against tough defenses lately, and both teams have solid defenses that can limit his mobility. He might have a few chances to run, but with how well the Broncos defend against rushing plays, it seems likely he won't hit that mark. The biggest risk is that he might get a lucky break or two, but overall, our numbers show a good chance he stays under 10.5 yards.

Arizona Cardinals vs Denver Broncos: Elijah Higgins Over 12.5 Receiving Yards (-111)

Betting on Elijah Higgins to get over 12.5 receiving yards looks solid at these odds. Our numbers suggest it's almost a toss-up, which means there's a fair chance he can hit that mark. The Cardinals are playing at home, and Higgins has shown he can step up in games like this, especially when the team needs him to help move the ball. However, the main risk is that the Broncos have a pretty tough defense. They can sometimes make it hard for receivers to get open. Still, if Higgins finds a few opportunities, he could easily go over that total. It's worth a shot given the price and his potential to shine in front of the home crowd.

Arizona Cardinals vs Denver Broncos: Elijah Higgins Over 12.5 Receiving Yards (Alt) (-111)

Betting on Elijah Higgins to get over 12.5 receiving yards at -111 seems like a solid choice. The game between the Arizona Cardinals and the Denver Broncos looks like a good chance for Higgins to make some plays, especially since both teams are still figuring things out. With the game being at home for the Cardinals, they might lean on their young players like Higgins to step up. Our numbers show this pick is close to a coin flip, so it's not guaranteed. The biggest risk here is that the Broncos' defense can be tough at times, which could limit Higgins' opportunities. Still, if he gets a few chances, he should be able to clear that 12.5 mark.

That is everything our model likes in this game. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.