Los Angeles Rams vs Buffalo Bills Prediction & Picks, October 12, 2026

For this game, we need both teams to score less than 54.5 points combined. The Los Angeles Rams and Buffalo Bills are both solid teams, but their recent performances suggest a lower-scoring game is more likely. The Rams' offense has been inconsistent, and the Bills might face a tough time breaking through the Rams' defense. Our numbers show this matchup is close to a coin flip, with a predicted total of about 51.5 points. The biggest risk is that both offenses could surprise us, but recent trends lean toward a lower score. It's worth considering that both teams may struggle to find their rhythm tonight.

Los Angeles Rams vs Buffalo Bills: Under 29.5 Team Total Points (-114)

The Rams' offense has struggled lately, especially against a tough Bills defense that knows how to shut down scoring. With both teams having played some intense games recently, the Rams might find it hard to put up points against Buffalo's strong unit. Betting on the Rams to score under 29.5 points seems reasonable here. Even though it's a close matchup, the Bills have shown they can keep teams from reaching their averages. The biggest risk is how well the Rams can find their rhythm at home, but they might just fall short against this solid defense.

Los Angeles Rams vs Buffalo Bills: Josh Allen Under 242.5 Passing Yards (-111)

For this game, we need Josh Allen to throw for less than 242.5 passing yards. The Rams' defense has been tough lately, making it hard for quarterbacks to rack up big yardage. With their pressure on the passer and solid coverage, it might be a challenge for Allen to find open receivers consistently. While Allen is a talented quarterback, he faces a strong Rams team at home. The close nature of this matchup could mean fewer passing opportunities as both teams likely stick to their game plans. Betting under 242.5 passing yards for Allen seems like a smart choice given the Rams' defensive strength and their chance of slowing him down tonight.

Los Angeles Rams vs Buffalo Bills: Kyren Williams Over 22.5 Receiving Yards (Alt) (-111)

Kyren Williams has been making waves lately, showing off his skills with some impressive performances. The Rams' offense needs a boost, and with Williams as a key target in the passing game, he's likely to rack up receiving yards against the Bills' defense. Betting on him to get over 22.5 receiving yards feels like a solid choice given how the Rams are using him. However, this matchup is a bit tricky since the Bills can put up a strong fight on defense. But with the Rams looking to get their passing game going and Williams being a favorite option for the quarterback, there's a good chance he can exceed that mark. Just remember, the game could go either way, and that adds a level of uncertainty.

Los Angeles Rams vs Buffalo Bills: Tyler Higbee Over 22.5 Receiving Yards (-111)

Tyler Higbee has been a solid target for the Los Angeles Rams, especially in a game at home where the team is set to face the Buffalo Bills. The Rams have had some time to prepare, and Higbee's ability to catch passes could be crucial against a Bills defense that can be tough but has shown weaknesses at times. With the way the Rams like to move the ball, Higbee could easily find ways to get open. The risk here is that the matchup is pretty even, so it's not a guaranteed win. However, with Higbee being involved in the Rams' game plan and needing to step up, betting on him to grab over 22.5 receiving yards seems like a reasonable call. Fans should expect him to get some opportunities to shine.

That is the full board for this game. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.