Chicago Bears vs New England Patriots Prediction & Picks, October 22, 2026

The bet on Caleb Williams to throw over 244.5 passing yards is looking solid at -111 odds. He's been showing some great form lately, and the Chicago Bears' defense has had trouble stopping passing games. With Williams at home, he should feel comfortable and confident to air it out, especially since the matchup feels pretty even. The biggest risk here is that the game could be tight, which might lead to a more conservative play style. However, with the Bears needing to keep pace against the New England Patriots, they might just let Williams do his thing and take some chances down the field. This could be a fun one to watch!

Chicago Bears vs New England Patriots: Caleb Williams Over 244.5 Passing Yards (Alt) (-111)

The odds for Caleb Williams to throw over 244.5 passing yards look pretty good at -111. Our numbers show this matchup between the Chicago Bears and New England Patriots is almost a coin flip, which means it could go either way, but there's a solid chance Williams can shine. He's been in good form lately and should have some chances against a Patriots defense that can struggle at times. One risk to watch is how closely matched both teams are, which might limit big plays. If the Bears' offense can stay consistent and Williams finds his rhythm early, he could easily rack up those passing yards. It's a bit of a gamble, but with his talent and the opportunity in front of him, it's worth considering.

Chicago Bears vs New England Patriots: Kyle Williams Under 19.5 Receiving Yards (-111)

The Chicago Bears' defense has been tough against the pass this season, making it hard for wide receivers to rack up big numbers. Kyle Williams might struggle to find open space against them, especially since the Bears have shown they can shut down opposing offenses effectively. Betting on Kyle Williams to have under 19.5 receiving yards seems smart because our numbers show he has a good chance of falling short of that mark. The biggest risk is that the game could end up being closer than expected, allowing for more passing opportunities. Still, with the way the Bears are playing, it feels like a solid choice.

That is the whole read on this one. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.