Atlanta Falcons vs San Francisco 49ers Prediction & Picks, October 25, 2026

For this game, we need Kaelon Black to rush for less than 30 yards. The San Francisco 49ers have been good at limiting the run game, and last season they struggled against tight ends, but they are solid when it comes to stopping running backs. Black had a decent share of carries last season, but he won't get as many opportunities against a tough 49ers defense. The risk here is that Black could get lucky and break off a big run. However, with the 49ers focusing on stopping the run and Black not being the main focus of the offense, it seems more likely he will stay under that mark. It's a close matchup, but I like this bet to stay under 29.5 rushing yards for Black.

Atlanta Falcons vs San Francisco 49ers: Drake London Under 78.5 Receiving Yards (-112)

For Drake London to go under 78.5 receiving yards, the Falcons need to keep things moving smoothly, and the 49ers' defense might help with that. San Francisco has struggled against tight ends, but they can also clamp down on wide receivers. With their quarterback facing extra rushers on many dropbacks, it could be tougher for London to get those big plays, as the 49ers know how to put pressure on the offense. While London has talent, the matchup is tricky since the 49ers are known for their solid defense. They tend to limit big yardage plays, especially when they're on the road. The risk here is that both teams are pretty close in strength, which could lead to a surprising game. Overall, betting on London to stay under 78.5 yards looks promising.

Atlanta Falcons vs San Francisco 49ers: Jahan Dotson Under 29.5 Receiving Yards (-112)

The San Francisco 49ers have a solid defense, but they struggle against tight ends, allowing more touchdowns than most teams. Jahan Dotson, playing for the Atlanta Falcons, might find it tough to rack up receiving yards in this matchup. The 49ers' defense brings pressure, which could limit his chances to get open. Betting on Dotson to have under 29.5 receiving yards seems smart here. Since the odds are close to even, it's a bit of a toss-up, but with the way the 49ers defend the position, it looks like he may not reach that number. Just remember, the game can always surprise us!

That is everything our model likes in this game. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.