Arizona Cardinals vs Denver Broncos Prediction & Picks, October 25, 2026

The Arizona Cardinals have been throwing the ball well lately, getting more out of their passing game than their running game. Their quarterback has faced extra pressure on a good number of dropbacks, but he's still shown he can make plays. Playing at home gives them a slight boost, and they're up against a Denver Broncos team that has struggled on the road. Betting on the Cardinals to win could be a smart move since they have a decent chance to pull this off as an underdog. However, the Broncos' quarterback also faced a lot of pressure this season, so both teams are in similar situations. The risk here is that the Broncos have a good record of staying under the total after games that didn't see many points, which can affect scoring.

Arizona Cardinals vs Denver Broncos: Bo Nix Over 219.5 Passing Yards (Alt) (-110)

Bo Nix has been on a solid run, averaging almost 15 fantasy points across his last 15 games. The Arizona Cardinals tend to rely more on their passing game, getting better results through the air than on the ground. This could play into Nix's hands, especially since the Broncos' defense has struggled against tight ends and has allowed a fair number of passing yards. While this matchup is rated close to a coin flip, Bo could face some extra pressure, as both quarterbacks have seen a good number of rushers on their dropbacks. If he can handle that pressure, he's got a good shot at exceeding 219.5 passing yards. Just remember, it's not a sure thing, and the defense might surprise us.

Arizona Cardinals vs Denver Broncos: Elijah Higgins Over 12.5 Receiving Yards (Alt) (-110)

The odds of over 12.5 receiving yards for Elijah Higgins look tempting. The Arizona Cardinals have shown they get better results when they throw the ball rather than run it, which could lead to more opportunities for Higgins to catch passes. Plus, the Denver Broncos have had trouble defending tight ends, allowing an average of 0.4 touchdowns a game. This could open up space for Higgins to make some plays. However, it's worth noting that both teams have had mixed results against the spread, making this matchup quite close. With both quarterbacks facing extra pressure on a good number of their dropbacks, it might be a tough game for scoring. Still, if the Cardinals stick to their passing game, Higgins could easily surpass that yard mark.

Arizona Cardinals vs Denver Broncos: Michael Wilson Over 48.5 Receiving Yards (-110)

Michael Wilson needs to catch more than 48.5 receiving yards tonight for this bet to win. The Arizona Cardinals have had success throwing the ball, and their quarterback has been better when targeting receivers rather than running. Wilson has a good shot at getting those yards, especially since the Denver Broncos struggled against tight ends last season, which could open up space for him. While both teams have faced extra rushers often, Wilson's chances look strong with the Cardinals focusing on the pass. The most concrete risk here is that the Broncos have a decent defense, which could make it tough for Wilson to find open space. Still, with the way the Cardinals have been throwing, he has a solid chance to get over that number tonight.

That is the full board for this game. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.