Philadelphia 76ers vs Cleveland Cavaliers Prediction & Picks, October 22, 2026

Anfernee Simons has been scoring well lately, showing that he can find the basket consistently. In this game against the Cleveland Cavaliers, he should have plenty of chances to rack up points. The Cavaliers often allow their opponents a lot of three-point attempts, and Simons is known for his shooting from beyond the arc, so this could play right into his hands. The pick is for Simons to score over 6.5 points. While he's a strong favorite to do this based on how he's been playing and the Cavaliers' defense, there is a risk that if the game is closely contested, he might not get as many shots as usual. Still, with the way he's been performing, this bet looks promising.

Philadelphia 76ers vs Cleveland Cavaliers: Joel Embiid Over 19.5 Points (-233)

Joel Embiid has been on fire lately, and with the game against the Cleveland Cavaliers coming up, he's in a great spot to score. The Cavaliers allow opponents to shoot a lot of threes, and they struggle to keep rebounds down, which gives Embiid plenty of chances to rack up points. He's a strong favorite to go over 19.5 points in this game. One thing to watch out for is that both teams have similar stats when it comes to turnovers, which could lead to a tighter game. However, with Embiid's scoring ability and the Cavaliers' defensive weaknesses, this looks like a solid bet. He has a great chance to shine tonight at the Wells Fargo Center.

Philadelphia 76ers vs Cleveland Cavaliers: LeBron James Over 12.5 Points (-278)

LeBron James is showing great scoring form, and he's up against the Philadelphia 76ers at the Wells Fargo Center. The 76ers allow teams to shoot a fair number of threes, which gives LeBron chances to hit some easy shots. Since 2018, Philly has let opponents take almost 34 threes each game, making it easier for a scorer like him to rack up points. While the 76ers do a decent job at forcing turnovers, LeBron's skill means he can still find ways to score. There's a small risk since both teams are pretty close in how they handle rebounds, but LeBron has been consistent. I think he can easily go over 12.5 points in this matchup.

That is the whole read on this one. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.