Chicago Cubs vs Miami Marlins Prediction and Picks, September 22, 2026

The Chicago Cubs have been struggling lately, winning just three of their last six games and losing five straight when playing away. This makes it tough for them, especially against a Miami Marlins team that is looking to bounce back. The Marlins have a real chance here, especially since they can keep balls in the yard at their park, meaning fewer home runs against them. Wrigley Field can be tricky, but the Marlins are rated as a solid underdog with a good shot at winning. The Cubs may have home field, but their recent form raises some questions. The most concrete risk is that the Cubs are still a tough team at home, so it's not guaranteed. Still, this is a good time to back the Marlins for a win.

Chicago Cubs vs Miami Marlins: Over 7 Total Runs (-110)

The Cubs have been scoring well lately, winning three of their last six games. Even though they've struggled on the road, playing at home in Wrigley Field can boost their offense. The Marlins have a tough time hitting home runs in their own park, but Wrigley is known for its lively atmosphere and can help both teams put runs on the board. This matchup looks like a close one, but the numbers suggest a total of about nine runs. With both teams having the potential to score, betting on over seven runs seems reasonable. Just remember, the Marlins' recent performance could make this a tricky game for scoring.

That is our read — no bet on this board is a sure thing. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.