Philadelphia 76ers vs Cleveland Cavaliers Prediction & Picks, October 22, 2026

Jaylon Tyson has been pretty quiet lately when it comes to scoring. He's been averaging under 8.5 points in both home and away games, which makes this bet look promising. The 76ers also tend to keep their opponents' scoring down, and they've been good at limiting shots, especially from deep. The Cavaliers are also no slouches on defense, so this matchup could be tough for Tyson. With both teams playing solid defense, it's a real possibility he won't hit that point mark. The biggest risk here is that he could still get hot unexpectedly, but overall, the numbers lean strongly toward him staying under 8.5 points tonight.

Philadelphia 76ers vs Cleveland Cavaliers: Jaylon Tyson Under 12.5 Pts + Rebs (-104)

Jaylon Tyson has been pretty consistent, but he hasn't been putting up huge numbers lately. He's averaging just under 1 assist, and his combined blocks and steals are quite low too. With the Philadelphia 76ers playing against the Cleveland Cavaliers, we think Tyson will struggle to rack up points and rebounds. Both teams have been allowing a fair number of shots from three-point range, but they also limit the overall scoring chances. The risk here is how close both teams are in terms of rebounds allowed, so Tyson could surprise. Still, we believe he'll stay under 12.5 combined points and rebounds in this matchup.

Philadelphia 76ers vs Cleveland Cavaliers: Jaylon Tyson Under 14.5 Pts + Rebs + Asts (-102)

Jaylon Tyson has been playing pretty well, especially on the road. He averages around 8.6 points and assists combined when away from home, but at home, that drops to about 6.5. Given this trend, betting on him to go under 14.5 points, rebounds, and assists seems like a solid choice. The Philadelphia 76ers are known for controlling rebounds and limiting opponent scoring chances, so Tyson might struggle to rack up stats in this game. The biggest risk here is that he could have an unexpected breakout. However, based on his recent performance and the matchup, going under 14.5 seems like a smart bet.

That is the full board for this game. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.