Los Angeles Rams vs Buffalo Bills Prediction & Picks, October 12, 2026

For this game, the total points need to stay under 54.5 for the bet to win. Both the Rams and the Bills have solid defenses that can keep scores down. Last season, the Rams allowed only 0.6 touchdowns per game to running backs, which shows they are tough to score against on the ground. Meanwhile, the Bills were also strong, giving up just 0.3 touchdowns to tight ends. The Rams' quarterback faced extra pressure on a good number of plays this season, which could hurt their scoring chances. This matchup is rated close to a coin flip, so it could go either way, but with both teams having solid defenses, the under seems like a smart pick. Just remember, it's always possible that things don't go as planned.

Los Angeles Rams vs Buffalo Bills: Under 25.5 Team Total Points (-111)

Betting on the Rams to score under 25.5 points feels like a smart choice at these odds. Their quarterback faced extra rushers more often than average, which can lead to mistakes and fewer scoring chances. Plus, the Rams' defense did well last season, allowing only 0.6 touchdowns per game to running backs, so they can be tough to break through. On the other hand, the Bills' quarterback also dealt with a lot of pressure, seeing extra rushers on a high percentage of his dropbacks. Both teams are closely matched, which makes it tough to expect a high-scoring game. The main risk is that both offenses can surprise us, but our numbers suggest keeping it low for this matchup.

Los Angeles Rams vs Buffalo Bills: Blake Corum Over 33.5 Rushing Yards (-110)

With the Rams facing the Bills at home, they might lean on Corum to help move the ball on the ground. The Bills' defense has been solid against tight ends but has allowed a fair amount of rushing yards. This game is expected to be tight, and Corum could see plenty of opportunities to rack up yards. One risk is that the Bills' defense has been tough against the run, giving up fewer touchdowns to running backs. Still, with Corum's involvement in the offense, he has a good chance to hit over 33.5 rushing yards. It's a close call, but Corum could surprise us with a strong performance.

Los Angeles Rams vs Buffalo Bills: Blake Corum Over 33.5 Rushing Yards (Alt) (-110)

Blake Corum has been a key player for the Rams, and he took a solid chunk of the carries last season. The Rams' offensive line is decent, and they'll rely on him to help establish the run against a tough Bills defense. The Bills have only allowed a few rushing touchdowns, but Corum should still find room to gain yards. The matchup is pretty tight, so there's a chance he might not hit the mark, especially if the Bills focus on stopping the run. Still, with the way he's been used, going over 33.5 rushing yards feels like a fair shot.

Los Angeles Rams vs Buffalo Bills: Kyren Williams Under 69.5 Rushing Yards (-110)

The Rams are up against the Bills, and this matchup looks tough for Kyren Williams. Last season, he handled just over half of the team's carries, but the Bills are known for being solid against the run. They let up fewer touchdowns to running backs than most teams, which adds pressure on Williams to break through their defense. While our numbers show a good chance for the under on his rushing yards, it's important to note that both teams have faced a lot of extra rushers lately. With the Rams' quarterback seeing extra pressure often, it could limit how much Williams can gain on the ground. This bet could be close, but the risk is there.

That is everything our model likes in this game. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.