The best college football bets for Week 5, as of September 22, 2026: 8 picks across the week's slate, each one our own number against the bookmaker's price.
On Saturday 26 September 2026,
Kent State Golden Flashes host
Ball State Cardinals in college football. The bet we are looking at is Under 40.5 Total Points. This wins if the two sides score fewer than 40.5 points between them. This is one of the bookmaker's alternate lines, not the main one, so the price is different. It was priced at +260 when we wrote this, so a $10 bet returns $36 if it lands. That price was showing at FanDuel. Our model leans this way, without being sure. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move. On Saturday 26 September 2026,
Bowling Green Falcons host
South Florida Bulls in college football. The bet we are looking at is Under 40.5 Total Points. This wins if the two sides score fewer than 40.5 points between them. This is one of the bookmaker's alternate lines, not the main one, so the price is different. It was priced at +285 when we wrote this, so a $10 bet returns $38.50 if it lands. That price was showing at FanDuel. Our model leans this way, without being sure. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move. On Saturday 26 September 2026,
Penn State Nittany Lions host
Wisconsin Badgers in college football. The bet we are looking at is Penn State Nittany Lions -18.5 Point Spread. On this line Penn State Nittany Lions give up 18.5 points before the game starts, so they have to win by more than 18.5. This is one of the bookmaker's alternate lines, not the main one, so the price is different. It was priced at +230 when we wrote this, so a $10 bet returns $33 if it lands. That price was showing at FanDuel. Our model leans this way, without being sure. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move. On Saturday 26 September 2026,
Purdue Boilermakers host
Notre Dame Fighting Irish in college football. The bet we are looking at is Under 50.5 Total Points. This wins if the two sides score fewer than 50.5 points between them. This is one of the bookmaker's alternate lines, not the main one, so the price is different. It was priced at +208 when we wrote this, so a $10 bet returns $30.80 if it lands. That price was showing at DraftKings. Our model leans this way, without being sure. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move. On Saturday 26 September 2026,
Wyoming Cowboys host
Hawaii Rainbow Warriors in college football. The bet we are looking at is Wyoming Cowboys -7.5 Point Spread. On this line Wyoming Cowboys give up 7.5 points before the game starts, so they have to win by more than 7.5. This is one of the bookmaker's alternate lines, not the main one, so the price is different. It was priced at +382 when we wrote this, so a $10 bet returns $48.20 if it lands. That price was showing at DraftKings. Our model has this one as a long shot, so keep the bet small. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move. On Saturday 26 September 2026,
Louisville Cardinals host
Wake Forest Demon Deacons in college football. The bet we are looking at is Under 50.5 Total Points. This wins if the two sides score fewer than 50.5 points between them. This is one of the bookmaker's alternate lines, not the main one, so the price is different. It was priced at +230 when we wrote this, so a $10 bet returns $33 if it lands. That price was showing at FanDuel. Our model leans this way, without being sure. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move. On Saturday 26 September 2026,
Georgia State Panthers host
Northern Illinois Huskies in college football. The bet we are looking at is Georgia State Panthers -14.5 Point Spread. On this line Georgia State Panthers give up 14.5 points before the game starts, so they have to win by more than 14.5. This is one of the bookmaker's alternate lines, not the main one, so the price is different. It was priced at +162 when we wrote this, so a $10 bet returns $26.20 if it lands. That price was showing at FanDuel. Our model leans this way, without being sure. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move. On Saturday 26 September 2026,
Florida Gators host
Ole Miss Rebels in college football. The bet we are looking at is Under 59 Total Points. This wins if the two sides score fewer than 59 points between them. This is one of the bookmaker's alternate lines, not the main one, so the price is different. It was priced at +110 when we wrote this, so a $10 bet returns $21 if it lands. That price was showing at Bovada. Our model likes this one a lot. Prices move, so check the price at your bookmaker before you back it. And if this one does not feel right to you, skipping it is a perfectly good move.