St Louis Blues vs Vegas Golden Knights Prediction & Picks, October 22, 2026

The St. Louis Blues play at home against the Vegas Golden Knights at the Enterprise Center. The Blues have won 5 of their last 10 games, showing they can compete well, especially on home ice. The Golden Knights have been strong too, winning 8 of their last 10, so this matchup is pretty even. Choosing the Blues for the third period moneyline makes sense since they can build energy from their crowd. However, the risk is that both teams are playing well, making it hard to predict the outcome. Still, the Blues have a solid chance to take the lead late and hold on for the win.

St Louis Blues vs Vegas Golden Knights: Under 5.5 Total Goals (+128)

The Vegas Golden Knights have been on fire, winning 8 of their last 10 games, which shows they know how to play well and score goals. However, the St. Louis Blues have been pretty solid too, winning 5 of their last 10. This matchup looks like it will be a tough battle, and both teams have strong defenses that can really limit scoring chances. With Vegas averaging about 12.9 blocked shots per game and St. Louis putting pressure on their opponents, I think we might see a lower-scoring game. The odds are pretty close on this one, but I'm leaning towards betting on under 5.5 total goals. Just remember, it could go either way, especially if one team catches fire on offense.

St Louis Blues vs Vegas Golden Knights: St Louis Blues 3-Way Moneyline (+160)

The St. Louis Blues are playing at home, and they've won 5 of their last 10 games. They've got a solid chance against the Vegas Golden Knights, who have been strong lately, winning 8 of their last 10. The Blues will look to take advantage of their home ice and the support from their fans at the Enterprise Center. However, the Golden Knights have been tough opponents, with good defensive stats like blocking almost 13 shots a game. Still, the Blues as an underdog at +160 offer some good value. They have the talent to pull off the upset, making this a worthwhile pick. Just keep in mind, the Golden Knights have been hot lately, and that could make things tricky for St. Louis.

That is the full board for this game. Prices can move before you get on, so check the board at your bookmaker. Bet what you can afford to lose. If betting stops being fun, take a break.